Tle1 MGI Mouse Gene Detail - MGI:104636 - transducin-like enhancer of split 1

Symbol

Tle1
Name

transducin-like enhancer of split 1
Synonyms

C230057C06Rik, Estm14, Grg1, Tle4l

Feature Type

protein coding gene
IDs

MGI:104636
NCBI Gene: 21885
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:72036042-72119130 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 36.06 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

1979 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104636	protein coding gene	Chr4:72028182-72124575 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028384	protein coding gene	Chr4:71326826-71411343 (-)
A/J	MGP_AJ_G0028345	protein coding gene	Chr4:68901754-68985432 (-)
AKR/J	MGP_AKRJ_G0028294	protein coding gene	Chr4:70696330-70779864 (-)
BALB/cJ	MGP_BALBcJ_G0028365	protein coding gene	Chr4:69058941-69143072 (-)
C3H/HeJ	MGP_C3HHeJ_G0028080	protein coding gene	Chr4:71235053-71318626 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028805	protein coding gene	Chr4:73877974-73961417 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026108	protein coding gene	Chr4:65522850-65606410 (-)
CAST/EiJ	MGP_CASTEiJ_G0027522	protein coding gene	Chr4:69207216-69295426 (-)
CBA/J	MGP_CBAJ_G0028049	protein coding gene	Chr4:76278860-76365686 (-)
DBA/2J	MGP_DBA2J_G0028198	protein coding gene	Chr4:68650566-68738170 (-)
FVB/NJ	MGP_FVBNJ_G0028164	protein coding gene	Chr4:67758191-67843968 (-)
LP/J	MGP_LPJ_G0028297	protein coding gene	Chr4:71686218-71772224 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028193	protein coding gene	Chr4:80073539-80159044 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028841	protein coding gene	Chr4:70760103-70844267 (-)
PWK/PhJ	MGP_PWKPhJ_G0027248	protein coding gene	Chr4:67103544-67188665 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027074	protein coding gene	Chr4:68274046-68358040 (-)
WSB/EiJ	MGP_WSBEiJ_G0027598	protein coding gene	Chr4:70831440-70919910 (-)

Human Ortholog

TLE1, TLE family member 1, transcriptional corepressor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TLE1, TLE family member 1, transcriptional corepressor
Synonyms

ESG, ESG1, GRG1, TLE-1
Links

HGNC:11837

NCBI Gene ID: 7088

neXtProt AC: NX_Q04724

UniProt: Q04724
Chr Location

9q21.32; chr9:81583683-81689547 (-) GRCh38

MGI Vertebrate Homology

Tle1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TLE1
Gene Tree

Tle1

less

Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

10
Radiation induced

1
Transgenic

1
Genomic Mutations

3 involving Tle1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

32
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1027
Tissues

202
cDNA Data

25
Literature Summary

43

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tle1

less

All Sequences

140
RefSeq

74
UniProt

7
CCDS

CCDS18274.1, CCDS71407.1

Ensembl

ENSMUSG00000008305 (Evidence)
NCBI Gene

21885

			Length	Strain/Species	Flank
genomic	ENSMUSG00000008305	Ensembl Gene Model \| MGI Sequence Detail	83089	C57BL/6J	± kb
transcript	ENSMUST00000030095	Ensembl \| MGI Sequence Detail	2569	Not Applicable
polypeptide	ENSMUSP00000030095	Ensembl \| MGI Sequence Detail	780	Not Applicable

less

UniProt

7 Sequences
Protein Ontology

PR:000016372 transducin-like enhancer protein 1

(term hierarchy)
InterPro Domains

IPR005617 Groucho/TLE, N-terminal Q-rich domain

IPR009146 Groucho/transducin-like enhancer

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q62440 2 sites, 1 O-linked glycan (2 sites)

less

All nucleic 36

cDNA 28

Primer pair 4

Other 4

Microarray probesets 4

less

MGD-MRK-26073, MGI:2178299, MGI:2444832

Summaries

All 97

Developmental Gene Expression 43

Gene Ontology 10

Phenotypes 12
Earliest

J:29516 Mallo M, et al., Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Dev Dyn. 1995 Nov;204(3):338-47
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tle1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42133	Chr4:72119070-72119165 (-)	12 bp
Tssr42132	Chr4:72118976-72118983 (-)	150 bp
Tssr42131	Chr4:72117308-72117345 (-)	1,803 bp
Tssr42130	Chr4:72117267-72117300 (-)	1,846 bp
Tssr42129	Chr4:72116545-72116556 (-)	2,579 bp
Tssr42128	Chr4:72111578-72111590 (-)	7,546 bp
Tssr42127	Chr4:72087817-72087822 (-)	31,310 bp
Tssr42126	Chr4:72087783-72087786 (-)	31,345 bp
Tssr42125	Chr4:72055353-72055366 (-)	63,770 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24