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Tff3 Gene Detail
Summary
  • Symbol
    Tff3
  • Name
    trefoil factor 3, intestinal
  • Synonyms
    ITF, mITF
  • Feature Type
    protein coding gene
  • IDs
    MGI:104638
    NCBI Gene: 21786
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:31344280-31348585 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104638
 protein coding gene Chr17:31344280-31348620 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023481
 protein coding gene Chr17:30858336-30862742 (-)
A/J MGP_AJ_G0023439
 protein coding gene Chr17:29855158-29859545 (-)
AKR/J MGP_AKRJ_G0023404
 protein coding gene Chr17:30100729-30105082 (-)
BALB/cJ MGP_BALBcJ_G0023444
 protein coding gene Chr17:29962302-29966713 (-)
C3H/HeJ MGP_C3HHeJ_G0023205
 protein coding gene Chr17:30485377-30489716 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023886
 protein coding gene Chr17:31931704-31936047 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021360
 protein coding gene Chr17:26995105-26999598 (-)
CAST/EiJ MGP_CASTEiJ_G0022706
 protein coding gene Chr17:30508119-30512590 (-)
CBA/J MGP_CBAJ_G0023180
 protein coding gene Chr17:33352129-33356464 (-)
DBA/2J MGP_DBA2J_G0023310
 protein coding gene Chr17:29272487-29276893 (-)
FVB/NJ MGP_FVBNJ_G0023280
 protein coding gene Chr17:29055865-29060238 (-)
LP/J MGP_LPJ_G0023388
 protein coding gene Chr17:31082500-31086921 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023298
 protein coding gene Chr17:32414183-32418589 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023928
 protein coding gene Chr17:30474639-30479055 (-)
PWK/PhJ MGP_PWKPhJ_G0022456
 protein coding gene Chr17:28088352-28092775 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022274
 protein coding gene Chr17:28460121-28464468 (-)
WSB/EiJ MGP_WSBEiJ_G0022768
 protein coding gene Chr17:30432668-30437009 (-)



Homology
more
  • Human Ortholog
    TFF3, trefoil factor 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFF3, trefoil factor 3
  • Synonyms
    ITF, P1B, TFI
  • Links
    NCBI Gene ID: 7033
    neXtProt AC: NX_Q07654
    UniProt: Q07654

  • Chr Location
    21q22.3; chr21:42311667-42315409 (-)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired intestinal mucosal healing and death from colitis after administration of dextran sulfate sodium. Mice show poor epithelial regeneration after injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1122
  • Tissues
    309
  • cDNA Data
    83
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21786 NCBI Gene Model | MGI Sequence Detail 4306 C57BL/6J ±  kb
    transcript NM_011575 RefSeq | MGI Sequence Detail 458 ZRU/MplStud  
    polypeptide Q62395 UniProt | EBI | MGI Sequence Detail 81 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 6
      cDNA 83
      Primer pair 6
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26075
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 36
      Diseases 3
      Gene Ontology 5
      Phenotypes 44
    • Earliest
      J:25263 Mashimo H, et al., Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression. Biochem Biophys Res Commun. 1995 May 5;210(1):31-7
    • Latest
      J:353482 Ortiz JA, et al., Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for beta-Cell Function During Aging. Diabetes. 2024 Sep 1;73(9):1447-1461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory