Ptx3 MGI Mouse Gene Detail - MGI:104641

Symbol

Ptx3
Name

pentraxin related gene
Synonyms

pentraxin 3, TSG-14

Feature Type

protein coding gene
IDs

MGI:104641
NCBI Gene: 19288
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:66127331-66133226 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 30.25 cM
Mapping Data

4 experiments

SNPs within 2kb

194 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104641	protein coding gene	Chr3:66127308-66133227 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027276	protein coding gene	Chr3:65365385-65371280 (+)
A/J	MGP_AJ_G0027237	protein coding gene	Chr3:63470356-63476251 (+)
AKR/J	MGP_AKRJ_G0027206	protein coding gene	Chr3:64781205-64787101 (+)
BALB/cJ	MGP_BALBcJ_G0027249	protein coding gene	Chr3:63296557-63302453 (+)
C3H/HeJ	MGP_C3HHeJ_G0026993	protein coding gene	Chr3:65053669-65059564 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027695	protein coding gene	Chr3:67812391-67818286 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025048	protein coding gene	Chr3:59844614-59850665 (+)
CAST/EiJ	MGP_CASTEiJ_G0026440	protein coding gene	Chr3:65028112-65034015 (+)
CBA/J	MGP_CBAJ_G0026968	protein coding gene	Chr3:69930120-69936015 (+)
DBA/2J	MGP_DBA2J_G0027104	protein coding gene	Chr3:62965232-62971127 (+)
FVB/NJ	MGP_FVBNJ_G0027072	protein coding gene	Chr3:61620312-61626206 (+)
LP/J	MGP_LPJ_G0027212	protein coding gene	Chr3:66287873-66293768 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027090	protein coding gene	Chr3:74517206-74523100 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027753	protein coding gene	Chr3:64678357-64684252 (+)
PWK/PhJ	MGP_PWKPhJ_G0026174	protein coding gene	Chr3:62729497-62735390 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025990	protein coding gene	Chr3:63873424-63879362 (+)
WSB/EiJ	MGP_WSBEiJ_G0026518	protein coding gene	Chr3:64819313-64825208 (+)

Human Ortholog

PTX3, pentraxin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTX3, pentraxin 3
Synonyms

TNFAIP5, TSG-14
Links

HGNC:9692

NCBI Gene ID: 5806

neXtProt AC: NX_P26022

UniProt: P26022
Chr Location

3q25.32; chr3:157436850-157443633 (+) GRCh38

MGI Vertebrate Homology

Ptx3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTX3
Gene Tree

Ptx3

Diseases

2 with human PTX3 associations

				Human Disease	Mouse Models
				cystic fibrosis IDs cystic fibrosis DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				invasive aspergillosis IDs invasive aspergillosis DOID:0050073

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

17 phenotypes from 2 alleles in 5 genetic backgrounds
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Ptx3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice display female subfertility due to abnormalities of the cumulus oophorus and are susceptible to invasive pulmonary aspergillosis associated with defective recognition of conidia by alveolar macrophages and dendritic cells and impaired induction of adaptive type 2 responses.

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

11
cDNA Data

7
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptx3

ZFIN ptx3a

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS17392.1

Ensembl

ENSMUSG00000027832 (Evidence)
NCBI Gene

19288

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027832	Ensembl Gene Model \| MGI Sequence Detail	5896	C57BL/6J	± kb
transcript	ENSMUST00000029421	Ensembl \| MGI Sequence Detail	1898	Not Applicable
polypeptide	ENSMUSP00000029421	Ensembl \| MGI Sequence Detail	381	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013490 pentraxin-related protein PTX3

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR030476 Pentaxin, conserved site

IPR001759 Pentraxin-related

IPR042837 Pentraxin-related protein PTX3
GlyGen

P48759 1 site

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All nucleic 13

Genomic 3

cDNA 8

Primer pair 2

Microarray probesets 6

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MGD-MRK-26079, MGI:2139768

Summaries

All 111

Developmental Gene Expression 10

Diseases 1

Gene Ontology 6

Phenotypes 53
Earliest

J:29540 Altmeyer A, et al., Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein. J Biol Chem. 1995 Oct 27;270(43):25584-90
Latest

J:343694 Granata V, et al., Genetic Deficiency of the Long Pentraxin 3 Affects Osteogenesis and Osteoclastogenesis in Homeostatic and Inflammatory Conditions. Int J Mol Sci. 2023 Nov 23;24(23)

TSS for Ptx3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29422	Chr3:66127330-66127348 (+)	8 bp
Tssr29423	Chr3:66127363-66127372 (+)	37 bp
Tssr29424	Chr3:66127381-66127386 (+)	53 bp
Tssr29425	Chr3:66127390-66127409 (+)	69 bp
Tssr29426	Chr3:66132939-66132941 (+)	5,609 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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