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Dll1 Gene Detail
Summary
  • Symbol
    Dll1
  • Name
    delta like canonical Notch ligand 1
  • Synonyms
    Delta1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104659
    NCBI Gene: 13388
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:15587616-15597134 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.95 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    241 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104659
 protein coding gene Chr17:15587616-15597275 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023172
 protein coding gene Chr17:13201507-13212661 (-)
A/J MGP_AJ_G0023138
 protein coding gene Chr17:12956443-12966470 (-)
AKR/J MGP_AKRJ_G0023108
 protein coding gene Chr17:12922134-12931648 (-)
BALB/cJ MGP_BALBcJ_G0023138
 protein coding gene Chr17:12907394-12917408 (-)
C3H/HeJ MGP_C3HHeJ_G0022899
 protein coding gene Chr17:13107311-13118154 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023581
 protein coding gene Chr17:13810563-13823973 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021093
 protein coding gene Chr17:10972568-10982001 (-)
CAST/EiJ MGP_CASTEiJ_G0022416
 protein coding gene Chr17:13021414-13031341 (-)
CBA/J MGP_CBAJ_G0022875
 protein coding gene Chr17:14257852-14270055 (-)
DBA/2J MGP_DBA2J_G0023008
 protein coding gene Chr17:12679980-12689548 (-)
FVB/NJ MGP_FVBNJ_G0022974
 protein coding gene Chr17:12525689-12535189 (-)
LP/J MGP_LPJ_G0023082
 protein coding gene Chr17:13193496-13205353 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022997
 protein coding gene Chr17:13799488-13811102 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023617
 protein coding gene Chr17:13156246-13166821 (-)
PWK/PhJ MGP_PWKPhJ_G0022164
 protein coding gene Chr17:12166447-12176126 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021994
 protein coding gene Chr17:12115728-12125183 (-)
WSB/EiJ MGP_WSBEiJ_G0022475
 protein coding gene Chr17:13478237-13489156 (-)



Homology
more
  • Human Ortholog
    DLL1, delta like canonical Notch ligand 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLL1, delta like canonical Notch ligand 1
  • Synonyms
    Delta, DELTA1, DL1, NEDBAS
  • Links
    NCBI Gene ID: 28514
    neXtProt AC: NX_O00548
    UniProt: O00548

  • Chr Location
    6q27; chr6:170282206-170306565 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    91 phenotypes from 8 alleles in 12 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos do not survive and have mesodermal segments with no cranio-caudal polarity and no epithelial somites develop; caudal sclerotome halves do not condense, the pattern. Mice heterozygous for a knock-out or ENU allele exhibit abnormal metabolic and immunological phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    117
  • GO References
    57
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2236
  • Tissues
    629
  • cDNA Data
    48
  • Literature Summary
    393
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014773 Ensembl Gene Model | MGI Sequence Detail 9519 C57BL/6J ±  kb
    transcript ENSMUST00000014917 Ensembl | MGI Sequence Detail 3581 Not Applicable  
    polypeptide ENSMUSP00000014917 Ensembl | MGI Sequence Detail 722 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000006523 delta-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR001774 Delta/Serrate/lag-2 (DSL) protein
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR011651 Notch ligand, N-terminal domain
      IPR051022 Notch Signaling and Cell Fate Determination
    • GlyGen
      Q61483 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 135
      Genomic 3
      cDNA 60
      Primer pair 23
      Other 49

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26099
    References
    more
    • Summaries
      All 548
      Developmental Gene Expression 393
      Gene Ontology 57
      Phenotypes 115
    • Earliest
      J:23089 Beermann F, et al., Chromosome segregation at meiosis I in female T(2;4)1Go/+ mice: no evidence for a decreased crossover frequency with maternal age. Chromosoma. 1987;95(1):1-7
    • Latest
      J:355651 El Azhar Y, et al., Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking. Development. 2024 Sep 15;151(18):dev202936
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory