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Pml Gene Detail
Summary
  • Symbol
    Pml
  • Name
    promyelocytic leukemia
  • Synonyms
    1200009E24Rik, Trim19
  • Feature Type
    protein coding gene
  • IDs
    MGI:104662
    NCBI Gene: 18854
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58125359-58157069 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.63 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    842 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104662
 protein coding gene Chr9:58125359-58157077 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034887
 protein coding gene Chr9:57489247-57523350 (-)
A/J MGP_AJ_G0034868
 protein coding gene Chr9:55628216-55661343 (-)
AKR/J MGP_AKRJ_G0034797
 protein coding gene Chr9:56923824-56957651 (-)
BALB/cJ MGP_BALBcJ_G0034860
 protein coding gene Chr9:55403535-55435271 (-)
C3H/HeJ MGP_C3HHeJ_G0034570
 protein coding gene Chr9:57407270-57440529 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035379
 protein coding gene Chr9:59081570-59114559 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032290
 protein coding gene Chr9:54910325-54944334 (-)
CAST/EiJ MGP_CASTEiJ_G0033891
 protein coding gene Chr9:57488068-57524729 (-)
CBA/J MGP_CBAJ_G0034541
 protein coding gene Chr9:61167830-61209170 (-)
DBA/2J MGP_DBA2J_G0034700
 protein coding gene Chr9:55482451-55515548 (-)
FVB/NJ MGP_FVBNJ_G0034642
 protein coding gene Chr9:54717965-54750583 (-)
LP/J MGP_LPJ_G0034783
 protein coding gene Chr9:57780944-57813906 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034685
 protein coding gene Chr9:62618911-62654024 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035401
 protein coding gene Chr9:56933629-56969482 (-)
PWK/PhJ MGP_PWKPhJ_G0033596
 protein coding gene Chr9:55528766-55562381 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033430
 protein coding gene Chr9:57221068-57254354 (-)
WSB/EiJ MGP_WSBEiJ_G0034004
 protein coding gene Chr9:56871664-56906686 (-)



Homology
more
  • Human Ortholog
    PML, PML nuclear body scaffold
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PML, PML nuclear body scaffold
  • Synonyms
    MYL, PP8675, RNF71, TRIM19
  • Links
    NCBI Gene ID: 5371
    neXtProt AC: NX_P29590
    UniProt: P29590

  • Chr Location
    15q24.1; chr15:73994673-74047827 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PML associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    25 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene have an increased susceptibility to infection and to induction of tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    149
  • GO References
    45
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    120
  • cDNA Data
    25
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036986 Ensembl Gene Model | MGI Sequence Detail 31711 C57BL/6J ±  kb
    transcript ENSMUST00000085673 Ensembl | MGI Sequence Detail 4481 Not Applicable  
    polypeptide ENSMUSP00000082816 Ensembl | MGI Sequence Detail 885 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 4
      cDNA 25
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-26102, MGI:2143109, MGI:2443400
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 45
      Phenotypes 65
    • Earliest
      J:29383 Goddard AD, et al., Cloning of the murine homolog of the leukemia-associated PML gene. Mamm Genome. 1995 Oct;6(10):732-7
    • Latest
      J:347585 Leon NY, et al., Y chromosome damage underlies testicular abnormalities in ATR-X syndrome. iScience. 2024 May 17;27(5):109629
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory