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Soat1 Gene Detail
Summary
  • Symbol
    Soat1
  • Name
    sterol O-acyltransferase 1
  • Synonyms
    8430426K15Rik, Acact, ACAT-1, hid
  • Feature Type
    protein coding gene
  • IDs
    MGI:104665
    NCBI Gene: 20652
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156255678-156301898 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 67.71 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1402 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104665
 protein coding gene Chr1:156252095-156301901 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016624
 protein coding gene Chr1:161381393-161432231 (-)
A/J MGP_AJ_G0016605
 protein coding gene Chr1:154889666-154939179 (-)
AKR/J MGP_AKRJ_G0016571
 protein coding gene Chr1:159629534-159669796 (-)
BALB/cJ MGP_BALBcJ_G0016566
 protein coding gene Chr1:155389365-155439343 (-)
C3H/HeJ MGP_C3HHeJ_G0016390
 protein coding gene Chr1:159750158-159801460 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017027
 protein coding gene Chr1:166898190-166953758 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014736
 protein coding gene Chr1:147092741-147142611 (-)
CAST/EiJ MGP_CASTEiJ_G0015970
 protein coding gene Chr1:159302974-159356378 (-)
CBA/J MGP_CBAJ_G0016365
 protein coding gene Chr1:172790080-172847989 (-)
DBA/2J MGP_DBA2J_G0016471
 protein coding gene Chr1:153846436-153896456 (-)
FVB/NJ MGP_FVBNJ_G0016469
 protein coding gene Chr1:152299352-152351277 (-)
LP/J MGP_LPJ_G0016542
 protein coding gene Chr1:162487813-162541605 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016494
 protein coding gene Chr1:180349282-180400244 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017063
 protein coding gene Chr1:159426444-159478690 (-)
PWK/PhJ MGP_PWKPhJ_G0015756
 protein coding gene Chr1:152930650-152981698 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015543
 protein coding gene Chr1:158176509-158222707 (-)
WSB/EiJ MGP_WSBEiJ_G0016032
 protein coding gene Chr1:159526421-159578515 (-)



Homology
more
  • Human Ortholog
    SOAT1, sterol O-acyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOAT1, sterol O-acyltransferase 1
  • Synonyms
    ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT
  • Links
    NCBI Gene ID: 6646
    neXtProt AC: NX_P35610
    UniProt: P35610

  • Chr Location
    1q25.2; chr1:179293714-179358680 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SOAT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 5 genetic backgrounds
    27 phenotypes from multigenic genotypes
    7 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants producing no protein or a truncated protein show depletion of cholesterol esters in adrenal cortex and peritoneal macrophages. Additionally, null mutants have reduced eye openings due to atrophy of meibomian glands or abnromal morphology and arrangement of medullary cells of all hair types.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    100
  • cDNA Data
    23
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20652 NCBI Gene Model | MGI Sequence Detail 46221 C57BL/6J ±  kb
    transcript NM_009230 RefSeq | MGI Sequence Detail 4785 ZRU/MplStud  
    polypeptide Q61263 UniProt | EBI | MGI Sequence Detail 540 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 26
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10717, MGD-MRK-1274, MGD-MRK-26105, MGI:1921100, MGI:2138610, MGI:87992, MGI:96088
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 57
    • Earliest
      J:166508 ARNESEN K, Constitutional difference in lipid content of adrenals in two strains of mice and their hybrids. Acta Endocrinol (Copenh). 1955 Apr;18(4):396-401
    • Latest
      J:349429 Bairos JA, et al., Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 May 16;1869(6):159512
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory