Hspe1 Gene Detail

Summary

• Symbol
  Hspe1
• Name
  heat shock protein 1 (chaperonin 10)
• Synonyms
  Hsp10, mitochondrial chaperonin 10

• Feature Type
  protein coding gene
• IDs
  MGI:104680
  NCBI Gene: 15528
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr1:55127307-55130476 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 28.02 cM, cytoband C1
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  150 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104680	protein coding gene	Chr1:55127291-55130476 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016031	protein coding gene	Chr1:54802017-54805192 (+)
A/J	MGP_AJ_G0016014	protein coding gene	Chr1:52895801-52898976 (+)
AKR/J	MGP_AKRJ_G0015970	protein coding gene	Chr1:54332812-54337780 (+)
BALB/cJ	MGP_BALBcJ_G0015969	protein coding gene	Chr1:52949094-52952282 (+)
C3H/HeJ	MGP_C3HHeJ_G0015801	protein coding gene	Chr1:54575353-54578528 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016422	protein coding gene	Chr1:57072560-57075735 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014144	protein coding gene	Chr1:48991197-48994341 (+)
CAST/EiJ	MGP_CASTEiJ_G0015383	protein coding gene	Chr1:53855465-53858645 (+)
CBA/J	MGP_CBAJ_G0015773	protein coding gene	Chr1:58682470-58685645 (+)
DBA/2J	MGP_DBA2J_G0015874	protein coding gene	Chr1:52320812-52324022 (+)
FVB/NJ	MGP_FVBNJ_G0015876	protein coding gene	Chr1:51669108-51672283 (+)
LP/J	MGP_LPJ_G0015946	protein coding gene	Chr1:55628829-55632004 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015896	protein coding gene	Chr1:61788639-61791815 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016469	protein coding gene	Chr1:54281290-54284465 (+)
PWK/PhJ	MGP_PWKPhJ_G0015169	protein coding gene	Chr1:51684034-51687425 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014950	protein coding gene	Chr1:53910511-53917011 (+)
WSB/EiJ	MGP_WSBEiJ_G0015446	protein coding gene	Chr1:53970205-53973486 (+)

Homology

• Human Ortholog
  HSPE1, heat shock protein family E (Hsp10) member 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  HSPE1, heat shock protein family E (Hsp10) member 1
  
• Synonyms
  CPN10, EPF, GROES, HSP10
• Links
  HGNC:5269

  NCBI Gene ID: 3336

  neXtProt AC: NX_P61604

  UniProt: P61604

  
  
• Chr Location
  2q33.1; chr2:197500140-197503449 (+)  GRCh38

---

• MGI Vertebrate Homology
  Hspe1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: HSPE1
• Gene Tree
  Hspe1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotype references
  

• All Mutations and Alleles
  39
• Chemically induced (other)
  1
• Gene trapped
  35
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Hspe1
• Find Mice (IMSR)
  22 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  16
• GO References
  8

Expression

• Assay Results
  724
• Tissues
  6
• cDNA Data
  162
• Literature Summary
  5

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase hspe1
  ZFIN hspe1

Sequences &
Gene Models

• All Sequences
  37
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS35570.1

• Ensembl
  ENSMUSG00000073676 (Evidence)
• NCBI Gene
  15528

Representative Sequences			Length	Strain/Species
genomic	15528	NCBI Gene Model | MGI Sequence Detail	3170	C57BL/6J
transcript	NM_008303	RefSeq | MGI Sequence Detail	788	C57BL/6
polypeptide	Q64433	UniProt | EBI | MGI Sequence Detail	102	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000008825 10 kDa heat shock protein, mitochondrial
  (term hierarchy)
• InterPro Domains
  IPR018369 Chaperonin GroES, conserved site
  IPR020818 GroES chaperonin family
  IPR037124 GroES chaperonin superfamily
  IPR011032 GroES-like superfamily
• GlyGen
  Q64433 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 164

  cDNA 162

  Primer pair 2

  
  

  Microarray probesets 5

Other
Accession IDs

MGD-MRK-27043

References

• Summaries
  All 51

  Developmental Gene Expression 5

  Gene Ontology 8

  Phenotypes 12
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:329326 Marta C, et al., Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos. Sci Rep. 2022 Sep 27;12(1):16152

TSS for Hspe1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6712	Chr1:55127110-55127153 (+)	-175 bp
Tssr6713	Chr1:55127465-55127511 (+)	181 bp