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Muc5ac Gene Detail
Summary
  • Symbol
    Muc5ac
  • Name
    mucin 5, subtypes A and C, tracheobronchial/gastric
  • Synonyms
    2210005L13Rik, MGM
  • Feature Type
    protein coding gene
  • IDs
    MGI:104697
    NCBI Gene: 17833
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141342709-141372968 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 87.23 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    691 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104697
 protein coding gene Chr7:141342695-141372968 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033241
 protein coding gene Chr7:146972586-147007324 (+)
A/J MGP_AJ_G0033222
 protein coding gene Chr7:142761748-142789749 (+)
AKR/J MGP_AKRJ_G0033155
 protein coding gene Chr7:146729427-146763645 (+)
BALB/cJ MGP_BALBcJ_G0033223
 protein coding gene Chr7:142495611-142525234 (+)
C3H/HeJ MGP_C3HHeJ_G0032938
 protein coding gene Chr7:146463473-146493428 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033735
 protein coding gene Chr7:152336057-152371429 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030708
 protein coding gene Chr7:143959016-143987107 (+)
CAST/EiJ MGP_CASTEiJ_G0032268
 protein coding gene Chr7:138787129-138821999 (+)
CBA/J MGP_CBAJ_G0032910
 protein coding gene Chr7:157498190-157530943 (+)
DBA/2J MGP_DBA2J_G0033062
 protein coding gene Chr7:140704900-140735842 (+)
FVB/NJ MGP_FVBNJ_G0033015
 protein coding gene Chr7:140617465-140647577 (+)
LP/J MGP_LPJ_G0033157
 protein coding gene Chr7:148460660-148493922 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033048
 protein coding gene Chr7:158134751-158164701 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033754
 protein coding gene Chr7:145686171-145718776 (+)
PWK/PhJ MGP_PWKPhJ_G0031972
 protein coding gene Chr7:133997443-134029097 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031818
 protein coding gene Chr7:132518179-132547568 (+)
WSB/EiJ MGP_WSBEiJ_G0032378
 protein coding gene Chr7:146644460-146676391 (+)



Homology
more
  • Human Ortholog
    MUC5AC, mucin 5AC, oligomeric mucus/gel-forming
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MUC5AC, mucin 5AC, oligomeric mucus/gel-forming
  • Synonyms
    leB, MUC5, mucin, TBM
  • Links
    NCBI Gene ID: 4586
    neXtProt AC: NX_P98088
    UniProt: P98088

  • Chr Location
    11p15.5; chr11:1157953-1201138 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Muc5ac mouse models; 1 with human MUC5AC associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to T. muris infection with persistent worm burden, goblet cell hyperplasia, and increased serum IFN-gamma despite a normal TH2-type immune response. A portion of mice show corneal opacity and poor tear quality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    29
  • cDNA Data
    9
  • Literature Summary
    48
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037974 Ensembl Gene Model | MGI Sequence Detail 30260 C57BL/6J ±  kb
    transcript ENSMUST00000155534 Ensembl | MGI Sequence Detail 10752 Not Applicable  
    polypeptide ENSMUSP00000122353 Ensembl | MGI Sequence Detail 3455 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR006207 Cystine knot, C-terminal
      IPR029034 Cystine-knot cytokine
      IPR050780 Mucin/von Willebrand/Thrombospondin superfamily
      IPR036084 Serine protease inhibitor-like superfamily
      IPR002919 Trypsin Inhibitor-like, cysteine rich domain
      IPR001846 von Willebrand factor, type D domain
      IPR001007 VWFC domain
      IPR014853 VWF/SSPO/Zonadhesin-like, cysteine-rich domain
      IPR025155 WxxW domain
    • GlyGen
      E9QAQ8 5 sites, 5 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 9
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-27060, MGI:1920903
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 48
      Diseases 1
      Gene Ontology 6
      Phenotypes 25
    • Earliest
      J:28082 Holmberg M, et al., The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters. Eur J Biochem. 1995 Jul 15;231(2):466-74
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory