About   Help   FAQ
Cct3 Gene Detail
Summary
  • Symbol
    Cct3
  • Name
    chaperonin containing TCP1 subunit 3
  • Synonyms
    Cctg, Tcp1-rs3, TriC-P5
  • Feature Type
    protein coding gene
  • IDs
    MGI:104708
    NCBI Gene: 12462
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88204442-88229073 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.79 cM, cytoband F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    413 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104708
 protein coding gene Chr3:88204423-88229074 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027388
 protein coding gene Chr3:88448047-88474524 (+)
A/J MGP_AJ_G0027352
 protein coding gene Chr3:85452838-85477500 (+)
AKR/J MGP_AKRJ_G0027318
 protein coding gene Chr3:87556814-87581484 (+)
BALB/cJ MGP_BALBcJ_G0027361
 protein coding gene Chr3:85543030-85567932 (+)
C3H/HeJ MGP_C3HHeJ_G0027104
 protein coding gene Chr3:87834389-87859050 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027807
 protein coding gene Chr3:91705686-91732197 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025160
 protein coding gene Chr3:81071974-81095714 (+)
CAST/EiJ MGP_CASTEiJ_G0026550
 protein coding gene Chr3:88039991-88070631 (+)
CBA/J MGP_CBAJ_G0027079
 protein coding gene Chr3:94831905-94857760 (+)
DBA/2J MGP_DBA2J_G0027215
 protein coding gene Chr3:84938012-84965868 (+)
FVB/NJ MGP_FVBNJ_G0027184
 protein coding gene Chr3:83210005-83235056 (+)
LP/J MGP_LPJ_G0027323
 protein coding gene Chr3:89440907-89467781 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027203
 protein coding gene Chr3:101059938-101086549 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027865
 protein coding gene Chr3:87309708-87335099 (+)
PWK/PhJ MGP_PWKPhJ_G0026283
 protein coding gene Chr3:84738511-84763260 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026101
 protein coding gene Chr3:86497466-86520591 (+)
WSB/EiJ MGP_WSBEiJ_G0026630
 protein coding gene Chr3:87666546-87691264 (+)



Homology
more
  • Human Ortholog
    CCT3, chaperonin containing TCP1 subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCT3, chaperonin containing TCP1 subunit 3
  • Synonyms
    CCTG, CCT-gamma, PIG48, TCP-1-gamma, TRIC5
  • Links
    NCBI Gene ID: 7203
    neXtProt AC: NX_P49368
    UniProt: P49368

  • Chr Location
    1q22; chr1:156308968-156367873 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption may exhibit lethality at E8.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    10
  • cDNA Data
    643
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12462 NCBI Gene Model | MGI Sequence Detail 24632 C57BL/6J ±  kb
transcript NM_009836 RefSeq | MGI Sequence Detail 1957 129/Sv  
polypeptide P80318 UniProt | EBI | MGI Sequence Detail 545 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000005151 T-complex protein 1 subunit gamma
    (term hierarchy)
  • PDB
    1GML, 1GN1
  • InterPro Domains
    IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
    IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family
    IPR002194 Chaperonin TCP-1, conserved site
    IPR027409 GroEL-like apical domain superfamily
    IPR027413 GroEL-like equatorial domain superfamily
    IPR012719 T-complex protein 1, gamma subunit
    IPR053374 TCP-1 chaperonin-containing T-complex
    IPR027410 TCP-1-like chaperonin intermediate domain superfamily
  • GlyGen
    P80318 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 648
    Genomic 1
    cDNA 645
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-16724, MGD-MRK-27071, MGI:2144350
References
more
  • Summaries
    All 62
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 13
    Phenotypes 14
  • Earliest
    J:18119 O'Bryan JP, et al., axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct;11(10):5016-31
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory