Wbp2 MGI Mouse Gene Detail - MGI:104709 - WW domain binding protein 2

Symbol

Wbp2
Name

WW domain binding protein 2

Feature Type

protein coding gene
IDs

MGI:104709
NCBI Gene: 22378
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:115969399-115977821 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.91 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

280 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104709	protein coding gene	Chr11:115969397-115977821 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019413	protein coding gene	Chr11:120164736-120174636 (-)
A/J	MGP_AJ_G0019382	protein coding gene	Chr11:114913752-114923120 (-)
AKR/J	MGP_AKRJ_G0019352	protein coding gene	Chr11:118340491-118351118 (-)
BALB/cJ	MGP_BALBcJ_G0019356	protein coding gene	Chr11:115325791-115334275 (-)
C3H/HeJ	MGP_C3HHeJ_G0019162	protein coding gene	Chr11:118691279-118700539 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019806	protein coding gene	Chr11:123842390-123851190 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017429	protein coding gene	Chr11:111931541-111939878 (-)
CAST/EiJ	MGP_CASTEiJ_G0018717	protein coding gene	Chr11:120040541-120052409 (-)
CBA/J	MGP_CBAJ_G0019134	protein coding gene	Chr11:128730664-128739030 (-)
DBA/2J	MGP_DBA2J_G0019245	protein coding gene	Chr11:114331200-114339586 (-)
FVB/NJ	MGP_FVBNJ_G0019237	protein coding gene	Chr11:113844516-113853258 (-)
LP/J	MGP_LPJ_G0019315	protein coding gene	Chr11:120544015-120554207 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019270	protein coding gene	Chr11:127827570-127836032 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019844	protein coding gene	Chr11:118996783-119009436 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0018274	protein coding gene	Chr11:118750798-118760555 (-)
WSB/EiJ	MGP_WSBEiJ_G0018769	protein coding gene	Chr11:118955676-118967671 (-)

Human Ortholog

WBP2, WW domain binding protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WBP2, WW domain binding protein 2
Synonyms

DFNB107, GRAMD6, WBP-2
Links

HGNC:12738

NCBI Gene ID: 23558

neXtProt AC: NX_Q969T9

UniProt: Q969T9
Chr Location

17q25.1; chr17:75845699-75856507 (-) GRCh38

MGI Vertebrate Homology

Wbp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WBP2
Gene Tree

Wbp2

Diseases

1 with human WBP2 associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness 107 IDs autosomal recessive nonsyndromic deafness 107 DOID:0080262 OMIM:617639

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

17 phenotypes from 1 allele in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

5
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show progressive high-frequency hearing loss, raised auditory brainstem response (ABR) thresholds, reduced ABR amplitudes, swelling of afferent terminals, inner hair cell synapse defects, and altered expression of AMPA receptor subunits and post-synaptic proteins.

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All GO Annotations

40
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

224
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wbp2

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All Sequences

57
RefSeq

6
UniProt

4
CCDS

CCDS25657.1, CCDS83934.1

Ensembl

ENSMUSG00000034341 (Evidence)
NCBI Gene

22378

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034341	Ensembl Gene Model \| MGI Sequence Detail	8423	C57BL/6J	± kb
transcript	ENSMUST00000074628	Ensembl \| MGI Sequence Detail	1826	Not Applicable
polypeptide	ENSMUSP00000074204	Ensembl \| MGI Sequence Detail	261	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029854 WW domain-binding protein 2

(term hierarchy)
InterPro Domains

IPR004182 GRAM domain

IPR044852 WW domain-binding protein 2-like
GlyGen

P97765 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 225

cDNA 225

Microarray probesets 3

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MGD-MRK-27072

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 16
Earliest

J:27757 Sudol M, et al., Characterization of a novel protein-binding module--the WW domain. FEBS Lett. 1995 Aug 1;369(1):67-71
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111846	Chr11:115977755-115977805 (-)	41 bp
Tssr111845	Chr11:115971489-115971501 (-)	6,326 bp
Tssr111844	Chr11:115971442-115971454 (-)	6,373 bp
Tssr111843	Chr11:115971167-115971179 (-)	6,648 bp
Tssr111842	Chr11:115971106-115971142 (-)	6,697 bp
Tssr111841	Chr11:115971089-115971100 (-)	6,726 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24