Gt(ROSA)26Sor Gene Detail

Summary

• Symbol
  Gt(ROSA)26Sor
• Name
  gene trap ROSA 26, Philippe Soriano
• Synonyms
  beta geo, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1

• Feature Type
  lncRNA gene
• IDs
  MGI:104735
  NCBI Gene: 14910
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr6:113044389-113054205 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 52.73 cM
• Mapping Data
  5 experiments

Strain
Comparison

• SNPs within 2kb
  191 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104735	lncRNA gene	Chr6:113043843-113054294 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0004335	antisense lncRNA gene	Chr6:115548703-115560361 (-)
A/J	MGP_AJ_G0004312	antisense lncRNA gene	Chr6:111139399-111149261 (-)
AKR/J	MGP_AKRJ_G0004295	antisense lncRNA gene	Chr6:114128614-114138515 (-)
BALB/cJ	MGP_BALBcJ_G0004298	antisense lncRNA gene	Chr6:111086531-111096539 (-)
C3H/HeJ	MGP_C3HHeJ_G0004206	antisense lncRNA gene	Chr6:70161689-70172315 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0004448	antisense lncRNA gene	Chr6:118559794-118569728 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0003916	antisense lncRNA gene	Chr6:108147135-108157094 (-)
CAST/EiJ	MGP_CASTEiJ_G0004209	antisense lncRNA gene	Chr6:114550254-114560159 (-)
CBA/J	MGP_CBAJ_G0004241	antisense lncRNA gene	Chr6:123240581-123250541 (-)
DBA/2J	MGP_DBA2J_G0004256	antisense lncRNA gene	Chr6:110225220-110235260 (-)
FVB/NJ	MGP_FVBNJ_G0004273	antisense lncRNA gene	Chr6:109216346-109226211 (-)
LP/J	MGP_LPJ_G0004336	antisense lncRNA gene	Chr6:115605897-115616153 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0004264	antisense lncRNA gene	Chr6:127523028-127532908 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0004445	antisense lncRNA gene	Chr6:114141999-114152826 (-)
PWK/PhJ	MGP_PWKPhJ_G0004162	antisense lncRNA gene	Chr6:109169048-109178894 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0004105	antisense lncRNA gene	Chr6:112959592-112970006 (-)
WSB/EiJ	MGP_WSBEiJ_G0004246	antisense lncRNA gene	Chr6:114509521-114520912 (-)

Homology

• Human Ortholog
  THUMPD3-AS1, THUMPD3 antisense RNA 1

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  THUMPD3-AS1, THUMPD3 antisense RNA 1
  
• Synonyms
  SETD5-AS1
• Links
  HGNC:44478

  NCBI Gene ID: 440944

  
  
• Chr Location
  3p25.3; chr3:9349689-9398625 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gt(ROSA)26Sor stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: THUMPD3-AS1
• Gene Tree
  Gt(ROSA)26Sor
  

Human Diseases

• Mutations/Alleles
  66 with disease annotations

• References
  86 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2123 phenotypes from multigenic genotypes
  92 images
  19531 phenotype references
  

• All Mutations and Alleles
  1762
• Endonuclease-mediated
  339
• Gene trapped
  176
• Spontaneous
  1
• Targeted
  1245
• Genomic Mutations
  1 involving Gt(ROSA)26Sor
• Find Mice (IMSR)
  994 strains or lines available
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for the original gene trap insertion and a targeted mutation mimicking the original gene trap exhibit no abnormal phenotype.

Expression

• Assay Results
  739
• Tissues
  13
• cDNA Data
  42
• Literature Summary
  16

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  36
• RefSeq
  3

• Ensembl
  ENSMUSG00000086429 (Evidence)
• NCBI Gene
  14910

Representative Sequences			Length	Strain/Species
genomic	14910	NCBI Gene Model | MGI Sequence Detail	9817	C57BL/6J
transcript	NR_027008	RefSeq | MGI Sequence Detail	1230	ZRU/MplStud

Molecular
Reagents

• All nucleic 48

  Genomic 3

  cDNA 43

  Primer pair 2

  
  

  Microarray probesets 2

Other
Accession IDs

MGD-MRK-27098, MGI:2141626

References

• Summaries
  All 19597

  Developmental Gene Expression 16

  Diseases 86

  Phenotypes 19531
• Earliest
  J:12736 Hayasaka I, et al., Polydactyly Nagoya, Pdn: A new mutant gene in the mouse. Jikken Dobutsu. 1980 Oct;29(4):391-5
• Latest
  J:359649 Carramolino L, et al., Cholesterol lowering depletes atherosclerotic lesions of smooth muscle cell-derived fibromyocytes and chondromyocytes. Nat Cardiovasc Res. 2024 Feb;3(2):203-220

TSS for Gt(ROSA)26Sor:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62430	Chr6:113054198-113054211 (-)	0 bp
Tssr62429	Chr6:113054142-113054164 (-)	52 bp
Tssr62428	Chr6:113053278-113053288 (-)	922 bp