Osm MGI Mouse Gene Detail - MGI:104749

Symbol

Osm
Name

oncostatin M
Synonyms

OncoM

Feature Type

protein coding gene
IDs

MGI:104749
NCBI Gene: 18413
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:4186831-4191027 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.94 cM
Mapping Data

3 experiments

SNPs within 2kb

138 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104749	protein coding gene	Chr11:4186420-4191027 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017980	protein coding gene	Chr11:1168750-1173356 (+)
A/J	MGP_AJ_G0017953	protein coding gene	Chr11:1180492-1185099 (+)
AKR/J	MGP_AKRJ_G0017917	protein coding gene	Chr11:1234591-1239197 (+)
BALB/cJ	MGP_BALBcJ_G0017921	protein coding gene	Chr11:1150392-1154998 (+)
C3H/HeJ	MGP_C3HHeJ_G0017734	protein coding gene	Chr11:1132350-1136956 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018374	protein coding gene	Chr11:1251588-1256194 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016032	protein coding gene	Chr11:1060807-1065234 (+)
CAST/EiJ	MGP_CASTEiJ_G0017296	protein coding gene	Chr11:1095866-1100499 (+)
CBA/J	MGP_CBAJ_G0017709	protein coding gene	Chr11:1497558-1502164 (+)
DBA/2J	MGP_DBA2J_G0017820	protein coding gene	Chr11:1084698-1089304 (+)
FVB/NJ	MGP_FVBNJ_G0017811	protein coding gene	Chr11:1117667-1122273 (+)
LP/J	MGP_LPJ_G0017890	protein coding gene	Chr11:1276124-1280730 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017837	protein coding gene	Chr11:1162992-1167599 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018413	protein coding gene	Chr11:1242958-1247565 (+)
PWK/PhJ	MGP_PWKPhJ_G0017077	protein coding gene	Chr11:1087250-1092042 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016873	protein coding gene	Chr11:1207409-1212083 (+)
WSB/EiJ	MGP_WSBEiJ_G0017350	protein coding gene	Chr11:1107105-1111721 (+)

Human Ortholog

OSM, oncostatin M

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OSM, oncostatin M
Links

HGNC:8506

NCBI Gene ID: 5008

neXtProt AC: NX_P13725

UniProt: P13725
Chr Location

22q12.2; chr22:30262829-30266851 (-) GRCh38

MGI Vertebrate Homology

Osm stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OSM
Gene Tree

Osm

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

5
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice display decreased noxious responses in models of acute thermal, mechanical, chemical, and visceral pain.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

22
cDNA Data

13
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS24382.1

Ensembl

ENSMUSG00000058755 (Evidence)
NCBI Gene

18413

			Length	Strain/Species	Flank
genomic	18413	NCBI Gene Model \| MGI Sequence Detail	4197	C57BL/6J	± kb
transcript	NM_001013365	RefSeq \| MGI Sequence Detail	1862	ZRU/MplStud
polypeptide	P53347	UniProt \| EBI \| MGI Sequence Detail	263	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012059 oncostatin-M

(term hierarchy)
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR001581 Leukemia inhibitory factor /oncostatin

IPR019827 Leukemia inhibitory factor /oncostatin, conserved site

IPR039578 Oncostatin-M
GlyGen

P53347 3 sites

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All nucleic 18

cDNA 13

Primer pair 5

Microarray probesets 2

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MGD-MRK-28040

Summaries

All 108

Developmental Gene Expression 14

Gene Ontology 9

Phenotypes 22
Earliest

J:15716 Conover JC, et al., Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells. Development. 1993 Nov;119(3):559-65
Latest

J:348729 Wang G, et al., Adipose-tissue Treg cells restrain differentiation of stromal adipocyte precursors to promote insulin sensitivity and metabolic homeostasis. Immunity. 2024 Apr 25;

TSS for Osm:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100110	Chr11:4186411-4186433 (+)	-409 bp
Tssr100111	Chr11:4186442-4186456 (+)	-382 bp
Tssr3413	Chr11:4186779-4186790 (+)	-46 bp
Tssr100112	Chr11:4186799-4186806 (+)	-28 bp
Tssr100113	Chr11:4186823-4186837 (+)	-1 bp
Tssr100114	Chr11:4186861-4186868 (+)	34 bp
Tssr3414	Chr11:4186877-4186882 (+)	49 bp
Tssr100115	Chr11:4187785-4187803 (+)	963 bp
Tssr100116	Chr11:4188107-4188116 (+)	1,281 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24