Nfasc MGI Mouse Gene Detail - MGI:104753

Symbol

Nfasc
Name

neurofascin
Synonyms

D430023G06Rik, mKIAA0756, NF155, NF186

Feature Type

protein coding gene
IDs

MGI:104753
NCBI Gene: 269116
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:132492428-132669535 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.42 cM
Mapping Data

4 experiments

SNPs within 2kb

5553 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104753	protein coding gene	Chr1:132492428-132669567 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016476	protein coding gene	Chr1:136065321-136241481 (-)
A/J	MGP_AJ_G0016459	protein coding gene	Chr1:131017156-131188737 (-)
AKR/J	MGP_AKRJ_G0016424	protein coding gene	Chr1:134862517-135036067 (-)
BALB/cJ	MGP_BALBcJ_G0016419	protein coding gene	Chr1:131344299-131522833 (-)
C3H/HeJ	MGP_C3HHeJ_G0016245	protein coding gene	Chr1:135018267-135196683 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016880	protein coding gene	Chr1:141104236-141279997 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014591	protein coding gene	Chr1:124167649-124341686 (-)
CAST/EiJ	MGP_CASTEiJ_G0015825	protein coding gene	Chr1:134013849-134198848 (-)
CBA/J	MGP_CBAJ_G0016217	protein coding gene	Chr1:145922045-146105415 (-)
DBA/2J	MGP_DBA2J_G0016324	protein coding gene	Chr1:129979525-130153982 (-)
FVB/NJ	MGP_FVBNJ_G0016323	protein coding gene	Chr1:128617301-128789286 (-)
LP/J	MGP_LPJ_G0016395	protein coding gene	Chr1:137368765-137550273 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016348	protein coding gene	Chr1:151709565-151910244 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016916	protein coding gene	Chr1:134619773-134803056 (-)
PWK/PhJ	MGP_PWKPhJ_G0015611	protein coding gene	Chr1:128963625-129142131 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015398	protein coding gene	Chr1:133583966-133761269 (-)
WSB/EiJ	MGP_WSBEiJ_G0015887	protein coding gene	Chr1:134621432-134801837 (-)

Human Ortholog

NFASC, neurofascin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFASC, neurofascin
Synonyms

NEDCPMD, NF, NRCAML
Links

HGNC:29866

NCBI Gene ID: 23114

neXtProt AC: NX_O94856

UniProt: O94856
Chr Location

1q32.1; chr1:204828651-205022822 (+) GRCh38

MGI Vertebrate Homology

Nfasc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NFASC
Gene Tree

Nfasc

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Phenotype Summary

25 phenotypes from 8 alleles in 8 genetic backgrounds
1 phenotype from multigenic genotypes
1 images
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

7
Radiation induced

1
Targeted

7
Transgenic

3
Genomic Mutations

3 involving Nfasc
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die within 6 to 7 days of birth, exhibit reduced nerve conduction velocity and abnormal paranodal junction formation.

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All GO Annotations

35
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

25
cDNA Data

119
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NFASC

Xenbase nfasc

ZFIN nfasca, nfascb

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All Sequences

142
RefSeq

86
UniProt

8
CCDS

CCDS35707.1, CCDS48358.1, CCDS48359.1

Ensembl

ENSMUSG00000026442 (Evidence)
NCBI Gene

269116

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026442	Ensembl Gene Model \| MGI Sequence Detail	177108	C57BL/6J	± kb
transcript	ENSMUST00000187861	Ensembl \| MGI Sequence Detail	4927	Not Applicable
polypeptide	ENSMUSP00000139955	Ensembl \| MGI Sequence Detail	1347	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011162 neurofascin

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013151 Immunoglobulin

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR026965 Neurofascin, immunoglobulin-like domain

IPR026966 Neurofascin/L1/NrCAM, C-terminal domain
GlyGen

Q810U3 15 sites, 37 N-linked glycans (14 sites), 1 O-linked glycan (1 site)

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All nucleic 121

cDNA 119

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-28044, MGI:2442229, MGI:3035338

Summaries

All 85

Developmental Gene Expression 14

Gene Ontology 18

Phenotypes 30
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nfasc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13666	Chr1:132669488-132669544 (-)	19 bp
Tssr13665	Chr1:132635077-132635089 (-)	34,452 bp
Tssr13664	Chr1:132635042-132635055 (-)	34,486 bp
Tssr13663	Chr1:132634987-132635021 (-)	34,531 bp
Tssr13662	Chr1:132562428-132562431 (-)	107,105 bp
Tssr13661	Chr1:132561943-132561960 (-)	107,583 bp
Tssr13660	Chr1:132554782-132554786 (-)	114,751 bp
Tssr13659	Chr1:132552211-132552228 (-)	117,315 bp
Tssr13658	Chr1:132544746-132544750 (-)	124,787 bp
Tssr13657	Chr1:132494741-132494754 (-)	174,787 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24