Gpx4 MGI Mouse Gene Detail - MGI:104767 - glutathione peroxidase 4

Symbol

Gpx4
Name

glutathione peroxidase 4
Synonyms

1700027O09Rik, mtPHGPx, PHGPx, phospholipid hydroperoxide glutathione peroxidase, snGPx, sperm nuclei glutathione peroxidase

Feature Type

protein coding gene
IDs

MGI:104767
NCBI Gene: 625249
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:79883000-79892273 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

4 experiments

SNPs within 2kb

280 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104767	protein coding gene	Chr10:79883000-79892273 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017480	protein coding gene	Chr10:80626675-80637483 (+)
A/J	MGP_AJ_G0017458	protein coding gene	Chr10:77806159-77816517 (+)
AKR/J	MGP_AKRJ_G0017419	protein coding gene	Chr10:79929212-79941522 (+)
BALB/cJ	MGP_BALBcJ_G0017420	protein coding gene	Chr10:78031206-78040387 (+)
C3H/HeJ	MGP_C3HHeJ_G0017243	protein coding gene	Chr10:80029788-80039887 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017874	protein coding gene	Chr10:83405561-83417218 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015562	protein coding gene	Chr10:74031167-74042468 (+)
CAST/EiJ	MGP_CASTEiJ_G0016810	protein coding gene	Chr10:80229947-80239212 (+)
CBA/J	MGP_CBAJ_G0017215	protein coding gene	Chr10:86635656-86648936 (+)
DBA/2J	MGP_DBA2J_G0017321	protein coding gene	Chr10:77021093-77033403 (+)
FVB/NJ	MGP_FVBNJ_G0017315	protein coding gene	Chr10:76203472-76213377 (+)
LP/J	MGP_LPJ_G0017392	protein coding gene	Chr10:81101565-81113060 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017341	protein coding gene	Chr10:88595108-88606237 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017915	protein coding gene	Chr10:79909931-79919236 (+)
PWK/PhJ	MGP_PWKPhJ_G0016591	protein coding gene	Chr10:76887119-76899357 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016380	protein coding gene	Chr10:78886924-78898978 (+)
WSB/EiJ	MGP_WSBEiJ_G0016870	protein coding gene	Chr10:79939823-79949108 (+)

Human Ortholog

GPX4, glutathione peroxidase 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPX4, glutathione peroxidase 4
Synonyms

GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx
Links

HGNC:4556

NCBI Gene ID: 2879

neXtProt AC: NX_P36969

UniProt: P36969
Chr Location

19p13.3; chr19:1103982-1106791 (+) GRCh38

MGI Vertebrate Homology

Gpx4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPX4
Protein SuperFamily

Glutathion_perox
Gene Tree

Gpx4

Diseases

3 with human GPX4 associations

				Human Disease	Mouse Models
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				spondylometaphyseal dysplasia Sedaghatian type IDs spondylometaphyseal dysplasia Sedaghatian type DOID:0112298 MESH:C535798 OMIM:250220 ORDO:93317 UMLS_CUI:C1855229

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

68 phenotypes from 11 alleles in 13 genetic backgrounds
3 phenotypes from multigenic genotypes
2 images
82 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

206
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

183
Targeted

15
Transgenic

1
Genomic Mutations

1 involving Gpx4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

82 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Gastrulation is impaired and homozygous mutant embryos consequently die during early embryonic development.

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All GO Annotations

43
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1415
Tissues

291
cDNA Data

25
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpx4

ZFIN gpx4a, gpx4b

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All Sequences

70
RefSeq

7
UniProt

6
CCDS

CCDS24007.1, CCDS35973.1

Ensembl

ENSMUSG00000075706 (Evidence)
NCBI Gene

625249

			Length	Strain/Species	Flank
genomic	625249	NCBI Gene Model \| MGI Sequence Detail	9274	C57BL/6J	± kb
transcript	NM_001037741	RefSeq \| MGI Sequence Detail	1021	C57BL/6
polypeptide	O70325	UniProt \| EBI \| MGI Sequence Detail	197	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008213 phospholipid hydroperoxide glutathione peroxidase GPX4

(term hierarchy)
PDB

5L71
EC

1.11.1.12, 1.11.1.9
InterPro Domains

IPR000889 Glutathione peroxidase

IPR029759 Glutathione peroxidase active site

IPR029760 Glutathione peroxidase conserved site

IPR036249 Thioredoxin-like superfamily
GlyGen

O70325 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 47

Genomic 1

cDNA 27

Primer pair 19

Microarray probesets 5

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MGD-MRK-28058

Summaries

All 149

Developmental Gene Expression 19

Gene Ontology 18

Phenotypes 82
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358342 Mo C, et al., Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis. Cell Metab. 2024 Aug 6;36(8):1839-1857.e12

TSS for Gpx4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94470	Chr10:79882843-79882864 (+)	-146 bp
Tssr94471	Chr10:79883081-79883098 (+)	90 bp
Tssr94472	Chr10:79889021-79889024 (+)	6,023 bp
Tssr94473	Chr10:79889393-79889404 (+)	6,399 bp
Tssr94474	Chr10:79889457-79889499 (+)	6,478 bp
Tssr94475	Chr10:79889800-79889818 (+)	6,809 bp
Tssr94476	Chr10:79889831-79889860 (+)	6,846 bp
Tssr94477	Chr10:79889863-79889877 (+)	6,870 bp
Tssr94478	Chr10:79889880-79889887 (+)	6,884 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24