Fkbp10 MGI Mouse Gene Detail - MGI:104769

Symbol

Fkbp10
Name

FK506 binding protein 10
Synonyms

65kDa, Fkbp1-rs, Fkbp6, FKBP65, Fkbp-rs1

Feature Type

protein coding gene
IDs

MGI:104769
NCBI Gene: 14230
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:100306523-100315650 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.47 cM
Mapping Data

14 experiments

SNPs within 2kb

291 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104769	protein coding gene	Chr11:100306520-100315666 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019154	protein coding gene	Chr11:103174052-103184516 (+)
A/J	MGP_AJ_G0019122	protein coding gene	Chr11:98863492-98873981 (+)
AKR/J	MGP_AKRJ_G0019091	protein coding gene	Chr11:101911462-101920145 (+)
BALB/cJ	MGP_BALBcJ_G0019096	protein coding gene	Chr11:99343925-99353038 (+)
C3H/HeJ	MGP_C3HHeJ_G0018905	protein coding gene	Chr11:102107715-102119591 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019545	protein coding gene	Chr11:106379715-106392793 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017171	protein coding gene	Chr11:96280943-96290019 (+)
CAST/EiJ	MGP_CASTEiJ_G0018459	protein coding gene	Chr11:103079825-103089649 (+)
CBA/J	MGP_CBAJ_G0018874	protein coding gene	Chr11:110805799-110814906 (+)
DBA/2J	MGP_DBA2J_G0018986	protein coding gene	Chr11:98401930-98411322 (+)
FVB/NJ	MGP_FVBNJ_G0018976	protein coding gene	Chr11:97933349-97943100 (+)
LP/J	MGP_LPJ_G0019055	protein coding gene	Chr11:103719113-103731016 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019007	protein coding gene	Chr11:110418155-110428876 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019583	protein coding gene	Chr11:102254699-102264485 (+)
PWK/PhJ	MGP_PWKPhJ_G0018222	protein coding gene	Chr11:99439339-99449814 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018014	protein coding gene	Chr11:101971037-101984825 (+)
WSB/EiJ	MGP_WSBEiJ_G0018508	protein coding gene	Chr11:102239446-102249166 (+)

Human Ortholog

FKBP10, FKBP prolyl isomerase 10

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FKBP10, FKBP prolyl isomerase 10
Synonyms

BRKS, BRKS1, FKBP65, hFKBP65, OI11, OI6, PPIASE, TLH1
Links

HGNC:18169

NCBI Gene ID: 60681

neXtProt AC: NX_Q96AY3

UniProt: Q96AY3
Chr Location

17q21.2; chr17:41812680-41823213 (+) GRCh38

MGI Vertebrate Homology

Fkbp10 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FKBP10
Gene Tree

Fkbp10

Diseases

1 with human FKBP10 associations

				Human Disease	Mouse Models
				osteogenesis imperfecta type 11 IDs osteogenesis imperfecta type 11 DOID:0110351 ICD10CM:Q78.0 OMIM:610968

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 1 allele in 2 genetic backgrounds
3 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

4
Gene trapped

3
Targeted

7
Genomic Mutations

3 involving Fkbp10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice do not survive birth, and embryos exhibit delayed growth, tissue fragility, decreased aorta wall thickness, craniofacial and forelimb anomalies, and connective tissue alterations. Mutant MEFs retain procollagen in the cell layer and show dilated endoplasmic reticulum.

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All GO Annotations

24
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

30
cDNA Data

107
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fkbp10

ZFIN fkbp10b

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All Sequences

47
RefSeq

4
UniProt

4
CCDS

CCDS25422.1

Ensembl

ENSMUSG00000001555 (Evidence)
NCBI Gene

14230

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001555	Ensembl Gene Model \| MGI Sequence Detail	9128	C57BL/6J	± kb
transcript	ENSMUST00000001595	Ensembl \| MGI Sequence Detail	2584	Not Applicable
polypeptide	ENSMUSP00000001595	Ensembl \| MGI Sequence Detail	581	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007532 peptidyl-prolyl cis-trans isomerase FKBP10

(term hierarchy)
EC

5.2.1.8
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR051989 FK506-binding protein-like isomerase

IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain

IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
GlyGen

Q61576 7 sites, 6 N-linked glycans (4 sites)

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All nucleic 108

cDNA 107

Primer pair 1

Microarray probesets 5

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MGD-MRK-28060, MGD-MRK-9809, MGI:2144131, MGI:95540

Summaries

All 63

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 23
Earliest

J:15604 Simek SL, et al., Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. Genomics. 1993 Nov;18(2):407-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fkbp10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104936	Chr11:100306541-100306546 (+)	21 bp
Tssr104937	Chr11:100306548-100306589 (+)	46 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24