About   Help   FAQ
Kcnj6 Gene Detail
Summary
  • Symbol
    Kcnj6
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 6
  • Synonyms
    GIRK2, KCNJ7, Kir3.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104781
    NCBI Gene: 16522
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:94549495-94798560 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 55.44 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2175 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104781
 protein coding gene Chr16:94545839-94798719 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023074
 protein coding gene Chr16:96008390-96283870 (-)
A/J MGP_AJ_G0023042
 protein coding gene Chr16:91487985-91739070 (-)
AKR/J MGP_AKRJ_G0023012
 protein coding gene Chr16:94292652-94543844 (-)
BALB/cJ MGP_BALBcJ_G0023044
 protein coding gene Chr16:92028903-92280147 (-)
C3H/HeJ MGP_C3HHeJ_G0022805
 protein coding gene Chr16:94807985-95072857 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023491
 protein coding gene Chr16:99074325-99343573 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020993
 protein coding gene Chr16:89341486-89595901 (-)
CAST/EiJ MGP_CASTEiJ_G0022324
 protein coding gene Chr16:95572715-95845884 (-)
CBA/J MGP_CBAJ_G0022774
 protein coding gene Chr16:103333111-103595510 (-)
DBA/2J MGP_DBA2J_G0022908
 protein coding gene Chr16:91378776-91628046 (-)
FVB/NJ MGP_FVBNJ_G0022882
 protein coding gene Chr16:90538814-90792971 (-)
LP/J MGP_LPJ_G0022978
 protein coding gene Chr16:95665543-95923655 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022903
 protein coding gene Chr16:107656108-107927196 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023509
 protein coding gene Chr16:94818318-95081022 (-)
PWK/PhJ MGP_PWKPhJ_G0022069
 protein coding gene Chr16:91644130-91901069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021899
 protein coding gene Chr16:94357097-94621826 (-)
WSB/EiJ MGP_WSBEiJ_G0022375
 protein coding gene Chr16:95079355-95347889 (-)



Homology
more
  • Human Ortholog
    KCNJ6, potassium inwardly rectifying channel subfamily J member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ6, potassium inwardly rectifying channel subfamily J member 6
  • Synonyms
    BIR1, GIRK-2, GIRK2, hiGIRK2, KATP-2, KATP2, KCNJ7, KIR3.2, KPLBS
  • Links
    NCBI Gene ID: 3763
    neXtProt AC: NX_P48051
    UniProt: P48051

  • Chr Location
    21q22.13; chr21:37607373-38121345 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCNJ6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    81 phenotypes from 4 alleles in 11 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    341 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A spontaneous mutation exhibits small size, ataxia, hypotonia, high periweaning mortality, Purkinje cell defects, and male sterility. Homozygotes for a targeted null mutation exhibit increased susceptibility to spontaneous and drug-induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1104
  • Tissues
    195
  • cDNA Data
    20
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043301 Ensembl Gene Model | MGI Sequence Detail 249066 C57BL/6J ±  kb
    transcript ENSMUST00000099508 Ensembl | MGI Sequence Detail 3097 Not Applicable  
    polypeptide ENSMUSP00000097108 Ensembl | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 11
      cDNA 21
      Primer pair 7
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-15467, MGD-MRK-28073
    References
    more
    • Summaries
      All 425
      Developmental Gene Expression 28
      Diseases 6
      Gene Ontology 14
      Phenotypes 341
    • Earliest
      J:5294 Rezai Z, et al., Abnormal rate of granule cell migration in the cerebellum of Weaver mutant mice. Dev Biol. 1972 Sep;29(1):17-26
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory