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Myo6 Gene Detail
Summary
  • Symbol
    Myo6
  • Name
    myosin VI
  • Synonyms
    Myo6rsv, rsv, Tlc
  • Feature Type
    protein coding gene
  • IDs
    MGI:104785
    NCBI Gene: 17920
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:80072313-80219011 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.98 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4833 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    8
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104785
 protein coding gene Chr9:80072262-80219011 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035079
 protein coding gene Chr9:80734233-80897841 (+)
A/J MGP_AJ_G0035060
 protein coding gene Chr9:77959476-78108395 (+)
AKR/J MGP_AKRJ_G0034988
 protein coding gene Chr9:79785206-79951439 (+)
BALB/cJ MGP_BALBcJ_G0035048
 protein coding gene Chr9:77590529-77738728 (+)
C3H/HeJ MGP_C3HHeJ_G0034760
 protein coding gene Chr9:80304336-80465757 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035571
 protein coding gene Chr9:82916974-83072712 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032478
 protein coding gene Chr9:77098935-77242894 (+)
CAST/EiJ MGP_CASTEiJ_G0034078
 protein coding gene Chr9:80656529-80815272 (+)
CBA/J MGP_CBAJ_G0034733
 protein coding gene Chr9:85875370-86038173 (+)
DBA/2J MGP_DBA2J_G0034891
 protein coding gene Chr9:77571114-77720093 (+)
FVB/NJ MGP_FVBNJ_G0034834
 protein coding gene Chr9:76784338-76932695 (+)
LP/J MGP_LPJ_G0034972
 protein coding gene Chr9:80973615-81136076 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034876
 protein coding gene Chr9:87100269-87264324 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035592
 protein coding gene Chr9:80014589-80171988 (+)
PWK/PhJ MGP_PWKPhJ_G0033782
 protein coding gene Chr9:77773836-77922071 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033618
 protein coding gene Chr9:80143257-80301521 (+)
WSB/EiJ MGP_WSBEiJ_G0034195
 protein coding gene Chr9:79938768-80091844 (+)



Homology
more
  • Human Ortholog
    MYO6, myosin VI
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO6, myosin VI
  • Synonyms
    DFNA22, DFNB37
  • Links
    NCBI Gene ID: 4646
    neXtProt AC: NX_Q9UM54
    UniProt: Q9UM54

  • Chr Location
    6q14.1; chr6:75749201-75919537 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Myo6 mouse models; 4 with human MYO6 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    87 phenotypes from 14 alleles in 17 genetic backgrounds
    9 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit deafness and related behavioral characteristics such as circling, head tossing and hyperactivity. Progressive degeneration of the cochlear hair cells and the organ of Corti is observed with one mutation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    85
  • cDNA Data
    100
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033577 Ensembl Gene Model | MGI Sequence Detail 146699 C57BL/6J ±  kb
    transcript ENSMUST00000184480 Ensembl | MGI Sequence Detail 4139 Not Applicable  
    polypeptide ENSMUSP00000139019 Ensembl | MGI Sequence Detail 1294 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      Genomic 6
      cDNA 102
      Primer pair 11
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-14657, MGD-MRK-28077, MGI:1891332, MGI:2670991, MGI:6160068
    References
    more
    • Summaries
      All 236
      Developmental Gene Expression 109
      Diseases 2
      Gene Ontology 24
      Phenotypes 66
    • Earliest
      J:5044 Deol MS, et al., Snell's waltzer, a new mutation affecting behaviour and the inner ear in the mouse. Genet Res. 1966 Dec;8(3):339-45
    • Latest
      J:354288 Young CA, et al., A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2. Development. 2024 Sep 1;151(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory