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Ltb Gene Detail
Summary
  • Symbol
    Ltb
  • Name
    lymphotoxin B
  • Synonyms
    LTbeta, lymphotoxin beta, p33, Tnfc, Tnfsf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104796
    NCBI Gene: 16994
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35413483-35415281 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104796
 protein coding gene Chr17:35413415-35415296 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023627
 protein coding gene Chr17:35342970-35344851 (+)
A/J MGP_AJ_G0023586
 protein coding gene Chr17:34164636-34166518 (+)
AKR/J MGP_AKRJ_G0023555
 protein coding gene Chr17:34645145-34647027 (+)
BALB/cJ MGP_BALBcJ_G0023593
 protein coding gene Chr17:34308841-34310723 (+)
C3H/HeJ MGP_C3HHeJ_G0023354
 protein coding gene Chr17:35050202-35052095 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024032
 protein coding gene Chr17:36688812-36690725 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021513
 protein coding gene Chr17:31936291-31938173 (+)
CAST/EiJ MGP_CASTEiJ_G0022850
 protein coding gene Chr17:35050642-35052529 (+)
CBA/J MGP_CBAJ_G0023332
 protein coding gene Chr17:38201279-38203173 (+)
DBA/2J MGP_DBA2J_G0023460
 protein coding gene Chr17:33492315-33494197 (+)
FVB/NJ MGP_FVBNJ_G0023427
 protein coding gene Chr17:33334345-33336238 (+)
LP/J MGP_LPJ_G0023537
 protein coding gene Chr17:35673093-35674974 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023449
 protein coding gene Chr17:37128780-37131938 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024077
 protein coding gene Chr17:34873746-34875627 (+)
PWK/PhJ MGP_PWKPhJ_G0022598
 protein coding gene Chr17:32328767-32330698 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022418
 protein coding gene Chr17:32881459-32883330 (+)
WSB/EiJ MGP_WSBEiJ_G0022914
 protein coding gene Chr17:34995910-34997791 (+)



Homology
more
  • Human Ortholog
    LTB, lymphotoxin beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LTB, lymphotoxin beta
  • Synonyms
    p33, TNFC, TNFSF3, TNLG1C
  • Links
    NCBI Gene ID: 4050
    neXtProt AC: NX_Q06643
    UniProt: Q06643

  • Chr Location
    6p21.33; chr6:31580525-31582522 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 6 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations lack peripheral lymph nodes, Peyer's patches, splenic germinal centers and follicular dendritic cells. Mutants exhibit lymphocytosis in the circulation and peritoneal cavity with infiltrations of the lung and liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    24
  • cDNA Data
    23
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16994 NCBI Gene Model | MGI Sequence Detail 1799 C57BL/6J ±  kb
    transcript NM_008518 RefSeq | MGI Sequence Detail 1122 ZRU/MplStud  
    polypeptide P41155 UniProt | EBI | MGI Sequence Detail 306 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 18
      cDNA 23
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16192, MGD-MRK-28088, MGI:2146913
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 11
      Gene Ontology 8
      Phenotypes 119
    • Earliest
      J:30783 Shacks SJ, et al., Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin. Cell Immunol. 1973 May;7(2):313-21
    • Latest
      J:353914 Bessell E, et al., Stromal cell and B cell dialogue potentiates IL-33-enriched lymphoid niches to support eosinophil recruitment and function during type 2 immunity. Cell Rep. 2024 Aug 27;43(8):114620
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory