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Pls3 Gene Detail
Summary
  • Symbol
    Pls3
  • Name
    plastin 3 (T-isoform)
  • Synonyms
    T-fimbrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104807
    NCBI Gene: 102866
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74829260-74918788 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1774 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104807
 protein coding gene ChrX:74829259-74918788 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035863
 protein coding gene ChrX:71640517-71736915 (-)
A/J MGP_AJ_G0035850
 protein coding gene ChrX:71869786-71956911 (-)
AKR/J MGP_AKRJ_G0035771
 protein coding gene ChrX:73706110-73808033 (-)
BALB/cJ MGP_BALBcJ_G0035832
 protein coding gene ChrX:70864672-70961180 (-)
C3H/HeJ MGP_C3HHeJ_G0035542
 protein coding gene ChrX:72132779-72225204 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036362
 protein coding gene ChrX:73944036-74040341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033199
 protein coding gene ChrX:71393112-71483892 (-)
CAST/EiJ MGP_CASTEiJ_G0034828
 protein coding gene ChrX:57438431-57535743 (-)
CBA/J MGP_CBAJ_G0035515
 protein coding gene ChrX:75882317-75969971 (-)
DBA/2J MGP_DBA2J_G0035673
 protein coding gene ChrX:71331220-71425023 (-)
FVB/NJ MGP_FVBNJ_G0035614
 protein coding gene ChrX:70599448-70691343 (-)
LP/J MGP_LPJ_G0035755
 protein coding gene ChrX:72451323-72545434 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035648
 protein coding gene ChrX:78561769-78662016 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036388
 protein coding gene ChrX:71499242-71592228 (-)
PWK/PhJ MGP_PWKPhJ_G0034525
 protein coding gene ChrX:55465539-55557146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034361
 protein coding gene ChrX:58270061-58363344 (-)
WSB/EiJ MGP_WSBEiJ_G0034967
 protein coding gene ChrX:70703515-70796619 (-)



Homology
more
  • Human Ortholog
    PLS3, plastin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLS3, plastin 3
  • Synonyms
    BMND18, DIH5, T-plastin
  • Links
    NCBI Gene ID: 5358
    neXtProt AC: NX_P13797
    UniProt: P13797

  • Chr Location
    Xq23; chrX:115561174-115650861 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Pls3 mouse models; 1 with human PLS3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for a knock-out allele exhibit osteoporotic phenotypes with increased bone resorption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    63
  • cDNA Data
    172
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016382 Ensembl Gene Model | MGI Sequence Detail 89529 C57BL/6J ±  kb
    transcript ENSMUST00000114058 Ensembl | MGI Sequence Detail 3032 Not Applicable  
    polypeptide ENSMUSP00000109692 Ensembl | MGI Sequence Detail 639 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 176
      cDNA 172
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28101, MGI:2147843, MGI:2147947
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:289366 Ezzell RM, et al., Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium. Development. 1989 Jun;106(2):407-19
    • Latest
      J:346759 Maus I, et al., Osteoclast-specific Plastin 3 knockout in mice fail to develop osteoporosis despite dramatic increased osteoclast resorption activity. JBMR Plus. 2024 Jan;8(1):ziad009
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory