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Pls1 Gene Detail
Summary
  • Symbol
    Pls1
  • Name
    plastin 1 (I-isoform)
  • Synonyms
    I-fimbrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104809
    NCBI Gene: 102502
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:95634695-95727359 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 50.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2834 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104809
 protein coding gene Chr9:95634695-95727364 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035138
 protein coding gene Chr9:96891377-96992745 (-)
A/J MGP_AJ_G0035119
 protein coding gene Chr9:93532875-93626435 (-)
AKR/J MGP_AKRJ_G0035051
 protein coding gene Chr9:95796561-95895181 (-)
BALB/cJ MGP_BALBcJ_G0035112
 protein coding gene Chr9:93216160-93313533 (-)
C3H/HeJ MGP_C3HHeJ_G0034822
 protein coding gene Chr9:96229706-96325818 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035632
 protein coding gene Chr9:99669904-99771227 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032533
 protein coding gene Chr9:91391609-91450106 (-)
CAST/EiJ MGP_CASTEiJ_G0034134
 protein coding gene Chr9:95958250-96055896 (-)
CBA/J MGP_CBAJ_G0034790
 protein coding gene Chr9:103125866-103245235 (-)
DBA/2J MGP_DBA2J_G0034952
 protein coding gene Chr9:93056998-93151798 (-)
FVB/NJ MGP_FVBNJ_G0034900
 protein coding gene Chr9:91904553-91998604 (-)
LP/J MGP_LPJ_G0035031
 protein coding gene Chr9:97154084-97252962 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034939
 protein coding gene Chr9:105134207-105241842 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035654
 protein coding gene Chr9:96028421-96124350 (-)
PWK/PhJ MGP_PWKPhJ_G0033841
 protein coding gene Chr9:93213873-93307416 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033676
 protein coding gene Chr9:96029359-96129442 (-)
WSB/EiJ MGP_WSBEiJ_G0034254
 protein coding gene Chr9:95892727-95996156 (-)



Homology
more
  • Human Ortholog
    PLS1, plastin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLS1, plastin 1
  • Synonyms
    DFNA76
  • Links
    NCBI Gene ID: 5357
    neXtProt AC: NX_Q14651
    UniProt: Q14651

  • Chr Location
    3q23; chr3:142596393-142713664 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation for this gene leads to altered intestinal morphology and physiology, increased brush border fragility and susceptibility to induced colitis, as well as a moderate and progressive form of hearing loss associated with defects in stereocilia morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    28
  • cDNA Data
    28
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 102502 NCBI Gene Model | MGI Sequence Detail 92665 C57BL/6J ±  kb
    transcript NM_001433804 RefSeq | MGI Sequence Detail 4043 C57BL/6  
    polypeptide Q3V0K9 UniProt | EBI | MGI Sequence Detail 630 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 3
      cDNA 28

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-28103, MGI:2143039
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:289366 Ezzell RM, et al., Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium. Development. 1989 Jun;106(2):407-19
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory