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Plaa Gene Detail
Summary
  • Symbol
    Plaa
  • Name
    phospholipase A2, activating protein
  • Synonyms
    D4Ertd618e, Ufd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104810
    NCBI Gene: 18786
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:94455751-94491481 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 43.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    760 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104810
 protein coding gene Chr4:94453371-94491481 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028450
 protein coding gene Chr4:94623947-94659553 (-)
A/J MGP_AJ_G0028413
 protein coding gene Chr4:91309037-91344533 (-)
AKR/J MGP_AKRJ_G0028360
 protein coding gene Chr4:93474760-93511101 (-)
BALB/cJ MGP_BALBcJ_G0028431
 protein coding gene Chr4:91556841-91592806 (-)
C3H/HeJ MGP_C3HHeJ_G0028144
 protein coding gene Chr4:94316263-94352924 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028870
 protein coding gene Chr4:98232241-98272903 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026164
 protein coding gene Chr4:86841864-86876168 (-)
CAST/EiJ MGP_CASTEiJ_G0027584
 protein coding gene Chr4:92185741-92222693 (-)
CBA/J MGP_CBAJ_G0028113
 protein coding gene Chr4:101227638-101273397 (-)
DBA/2J MGP_DBA2J_G0028263
 protein coding gene Chr4:91091666-91127360 (-)
FVB/NJ MGP_FVBNJ_G0028230
 protein coding gene Chr4:89956713-89992209 (-)
LP/J MGP_LPJ_G0028363
 protein coding gene Chr4:94944353-94981866 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028259
 protein coding gene Chr4:106991256-107030876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028908
 protein coding gene Chr4:93769535-93806977 (-)
PWK/PhJ MGP_PWKPhJ_G0027309
 protein coding gene Chr4:89249687-89289012 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027129
 protein coding gene Chr4:91182337-91219080 (-)
WSB/EiJ MGP_WSBEiJ_G0027662
 protein coding gene Chr4:93928601-93968418 (-)



Homology
more
  • Human Ortholog
    PLAA, phospholipase A2 activating protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAA, phospholipase A2 activating protein
  • Synonyms
    DOA1, NDMSBA, PLA2P, PLAP
  • Links
    NCBI Gene ID: 9373
    neXtProt AC: NX_Q9Y263
    UniProt: Q9Y263

  • Chr Location
    9p21.2; chr9:26903372-26947242 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO is embryonic lethal. A hypomorphic homozygous point mutation affects neuromuscular junctions and Purkinje cell development, causing early-onset neurodysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    17
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028577 Ensembl Gene Model | MGI Sequence Detail 35731 C57BL/6J ±  kb
    transcript ENSMUST00000107107 Ensembl | MGI Sequence Detail 2784 Not Applicable  
    polypeptide ENSMUSP00000102724 Ensembl | MGI Sequence Detail 794 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-28104, MGI:1277105, MGI:2140330, MGI:2140438, MGI:2140559
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:28587 Clark MA, et al., Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5418-22
    • Latest
      J:344874 Bai Y, et al., PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805. Autophagy. 2023 May;19(5):1562-1581
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory