Hnrnpa2b1 MGI Mouse Gene Detail - MGI:104819 - heterogeneous nuclear ribonucleoprotein A2/B1

Symbol

Hnrnpa2b1
Name

heterogeneous nuclear ribonucleoprotein A2/B1
Synonyms

9130414A06Rik, Hnrpa2, Hnrpa2b1

Feature Type

protein coding gene
IDs

MGI:104819
NCBI Gene: 53379
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr6:51437912-51446874 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 24.87 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

248 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104819	protein coding gene	Chr6:51437414-51448054 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030734	protein coding gene	Chr6:50649570-50658532 (-)
A/J	MGP_AJ_G0030704	protein coding gene	Chr6:48283507-48294213 (-)
AKR/J	MGP_AKRJ_G0030630	protein coding gene	Chr6:49967897-49976862 (-)
BALB/cJ	MGP_BALBcJ_G0030715	protein coding gene	Chr6:48639212-48651228 (-)
C3H/HeJ	MGP_C3HHeJ_G0030429	protein coding gene	Chr6:49985417-49994379 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031170	protein coding gene	Chr6:51771434-51780396 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028377	protein coding gene	Chr6:45955520-45965425 (-)
CAST/EiJ	MGP_CASTEiJ_G0029831	protein coding gene	Chr6:49753486-49762445 (-)
CBA/J	MGP_CBAJ_G0030402	protein coding gene	Chr6:53941252-53950215 (-)
DBA/2J	MGP_DBA2J_G0030552	protein coding gene	Chr6:48208176-48217138 (-)
FVB/NJ	MGP_FVBNJ_G0030504	protein coding gene	Chr6:47827186-47836149 (-)
LP/J	MGP_LPJ_G0030637	protein coding gene	Chr6:50618281-50627242 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030538	protein coding gene	Chr6:56599423-56608636 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031200	protein coding gene	Chr6:49886762-49895723 (-)
PWK/PhJ	MGP_PWKPhJ_G0029544	protein coding gene	Chr6:47810143-47820001 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029379	protein coding gene	Chr6:49226634-49236599 (-)
WSB/EiJ	MGP_WSBEiJ_G0029908	protein coding gene	Chr6:49873774-49883455 (-)

Human Ortholog

HNRNPA2B1, heterogeneous nuclear ribonucleoprotein A2/B1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HNRNPA2B1, heterogeneous nuclear ribonucleoprotein A2/B1
Synonyms

HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, OPMD2, RNPA2, SNRPB1
Links

HGNC:5033

NCBI Gene ID: 3181

neXtProt AC: NX_P22626

UniProt: P22626
Chr Location

7p15.2; chr7:26171151-26201529 (-) GRCh38

MGI Vertebrate Homology

Hnrnpa2b1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HNRNPA2B1
Gene Tree

Hnrnpa2b1

Diseases

2 with human HNRNPA2B1 associations

				Human Disease	Mouse Models
				inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2 IDs inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2 DOID:0111384 OMIM:615422
				inclusion body myopathy with Paget disease of bone and frontotemporal dementia IDs inclusion body myopathy with Paget disease of bone and frontotemporal dementia DOID:0050881 MESH:C563476 OMIM:PS167320 ORDO:52430

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

94
Endonuclease-mediated

4
Gene trapped

86
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

72
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

11
cDNA Data

397
Literature Summary

9

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hnrnpa2b1

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All Sequences

103
RefSeq

39
UniProt

4
CCDS

CCDS51773.1, CCDS51774.1, CCDS90046.1

Ensembl

ENSMUSG00000004980 (Evidence)
NCBI Gene

53379

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004980	Ensembl Gene Model \| MGI Sequence Detail	8963	C57BL/6J	± kb
transcript	ENSMUST00000203954	Ensembl \| MGI Sequence Detail	1703	Not Applicable
polypeptide	ENSMUSP00000145028	Ensembl \| MGI Sequence Detail	353	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008660 heterogeneous nuclear ribonucleoproteins A2/B1

(term hierarchy)
InterPro Domains

IPR021662 Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal

IPR034486 hnRNP A2/B1, RNA recognition motif 1

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

O88569 1 site, 1 O-linked glycan (1 site)

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All nucleic 400

cDNA 397

Primer pair 2

Other 1

Microarray probesets 4

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MGD-MRK-28113, MGI:1918855

Summaries

All 67

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 13
Earliest

J:23142 Ferreira J, et al., The biogenesis of the coiled body during early mouse development. Development. 1995 Feb;121(2):601-12
Latest

J:350584 Wang X, et al., hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility. Cell Rep. 2024 Feb 27;43(2):113769

TSS for Hnrnpa2b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60949	Chr6:51448009-51448049 (-)	-1,155 bp
Tssr60948	Chr6:51446849-51446857 (-)	21 bp
Tssr60947	Chr6:51446816-51446834 (-)	49 bp
Tssr60946	Chr6:51445431-51445449 (-)	1,434 bp
Tssr60945	Chr6:51444799-51444801 (-)	2,074 bp
Tssr60944	Chr6:51443931-51443972 (-)	2,922 bp
Tssr60943	Chr6:51443909-51443925 (-)	2,957 bp
Tssr60942	Chr6:51443811-51443815 (-)	3,061 bp
Tssr60941	Chr6:51443602-51443668 (-)	3,239 bp
Tssr60940	Chr6:51443357-51443384 (-)	3,503 bp
Tssr60939	Chr6:51443199-51443205 (-)	3,672 bp
Tssr60938	Chr6:51441475-51441495 (-)	5,389 bp
Tssr60937	Chr6:51441433-51441451 (-)	5,432 bp
Tssr60936	Chr6:51441426-51441430 (-)	5,446 bp
Tssr60935	Chr6:51440463-51440479 (-)	6,403 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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