Spata13 MGI Mouse Gene Detail - MGI:104838 - spermatogenesis associated 13

Symbol

Spata13
Name

spermatogenesis associated 13
Synonyms

ESTM11, mKIAA1112

Feature Type

protein coding gene
IDs

MGI:104838
NCBI Gene: 219140
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr14:60871450-61002005 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 31.77 cM
Mapping Data

3 experiments

SNPs within 2kb

3717 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104838	protein coding gene	Chr14:60722617-61002005 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021433	protein coding gene	Chr14:54963959-55110571 (+)
A/J	MGP_AJ_G0021392	protein coding gene	Chr14:53785616-53920250 (+)
AKR/J	MGP_AKRJ_G0021367	protein coding gene	Chr14:55698645-55839687 (+)
BALB/cJ	MGP_BALBcJ_G0021397	protein coding gene	Chr14:53741790-53877609 (+)
C3H/HeJ	MGP_C3HHeJ_G0021175	protein coding gene	Chr14:55357917-55499886 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021836	protein coding gene	Chr14:57673579-57827225 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019376	protein coding gene	Chr14:51808190-51939489 (+)
CAST/EiJ	MGP_CASTEiJ_G0020691	protein coding gene	Chr14:51746237-51888142 (+)
CBA/J	MGP_CBAJ_G0021142	protein coding gene	Chr14:59321594-59471905 (+)
DBA/2J	MGP_DBA2J_G0021265	protein coding gene	Chr14:53471661-53602565 (+)
FVB/NJ	MGP_FVBNJ_G0021243	protein coding gene	Chr14:52876700-53010495 (+)
LP/J	MGP_LPJ_G0021339	protein coding gene	Chr14:56021122-56161047 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021272	protein coding gene	Chr14:58678949-58820214 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021859	protein coding gene	Chr14:54852413-54991937 (+)
PWK/PhJ	MGP_PWKPhJ_G0020435	protein coding gene	Chr14:50120258-50257373 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020268	protein coding gene	Chr14:50804166-50941651 (+)
WSB/EiJ	MGP_WSBEiJ_G0020744	protein coding gene	Chr14:55170349-55307486 (+)

Human Ortholog

SPATA13, spermatogenesis associated 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPATA13, spermatogenesis associated 13
Synonyms

ARHGEF29, ASEF2
Links

HGNC:23222

NCBI Gene ID: 221178

neXtProt AC: NX_Q96N96

UniProt: Q96N96
Chr Location

13q12.12; chr13:23979802-24307074 (+) GRCh38

MGI Vertebrate Homology

Spata13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPATA13
Gene Tree

Spata13

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

21
Targeted

3
Genomic Mutations

1 involving Spata13
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

79 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile and overtly normal. Behavioral tests indicate that mutant mice exhibit submissive social hierarchy behavior and females exhibit increased voluntary activity in the dark phase of the light-dark cycle.

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All GO Annotations

28
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

49
cDNA Data

109
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SPATA13

Xenbase spata13

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All Sequences

114
RefSeq

37
UniProt

9
CCDS

CCDS49516.1, CCDS79328.1

Ensembl

ENSMUSG00000021990 (Evidence)
NCBI Gene

219140

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021990	Ensembl Gene Model \| MGI Sequence Detail	130556	C57BL/6J	± kb
transcript	ENSMUST00000022566	Ensembl \| MGI Sequence Detail	7517	Not Applicable
polypeptide	ENSMUSP00000022566	Ensembl \| MGI Sequence Detail	1244	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000015480 spermatogenesis-associated protein 13

(term hierarchy)
InterPro Domains

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q5DU57 1 site, 1 N-linked glycan (1 site)

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All nucleic 109

cDNA 109

Microarray probesets 5

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MGD-MRK-28132, MGI:1353612

Summaries

All 53

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 13
Earliest

J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Spata13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125945	Chr14:60872168-60872225 (+)	747 bp
Tssr125946	Chr14:60872228-60872239 (+)	784 bp
Tssr125947	Chr14:60873327-60873331 (+)	1,879 bp
Tssr125948	Chr14:60940363-60940380 (+)	68,922 bp
Tssr125949	Chr14:60940395-60940420 (+)	68,958 bp
Tssr125950	Chr14:60946760-60946785 (+)	75,323 bp
Tssr125951	Chr14:60946794-60946807 (+)	75,351 bp
Tssr125952	Chr14:60946844-60946932 (+)	75,438 bp
Tssr125953	Chr14:60946940-60946968 (+)	75,504 bp
Tssr125954	Chr14:60946969-60946982 (+)	75,526 bp
Tssr125955	Chr14:60970443-60970458 (+)	99,001 bp
Tssr125956	Chr14:60970475-60970491 (+)	99,033 bp
Tssr125957	Chr14:60987608-60987620 (+)	116,164 bp
Tssr125958	Chr14:60987656-60987671 (+)	116,214 bp
Tssr125959	Chr14:61000013-61000025 (+)	128,569 bp
Tssr125960	Chr14:61001233-61001237 (+)	129,785 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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