Inpp1 MGI Mouse Gene Detail - MGI:104848 - inositol polyphosphate-1-phosphatase

Symbol

Inpp1
Name

inositol polyphosphate-1-phosphatase
Synonyms

2300002C06Rik

Feature Type

protein coding gene
IDs

MGI:104848
NCBI Gene: 16329
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:52824586-52856847 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 26.99 cM
Mapping Data

5 experiments

SNPs within 2kb

1017 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104848	protein coding gene	Chr1:52824584-52856847 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016011	protein coding gene	Chr1:52309796-52345682 (-)
A/J	MGP_AJ_G0015993	protein coding gene	Chr1:50546913-50580920 (-)
AKR/J	MGP_AKRJ_G0015949	protein coding gene	Chr1:51637831-51670412 (-)
BALB/cJ	MGP_BALBcJ_G0015950	protein coding gene	Chr1:50372719-50406054 (-)
C3H/HeJ	MGP_C3HHeJ_G0015782	protein coding gene	Chr1:52020593-52053472 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016401	protein coding gene	Chr1:54499805-54535229 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014123	protein coding gene	Chr1:41289321-41322658 (+)
CAST/EiJ	MGP_CASTEiJ_G0015363	protein coding gene	Chr1:51516586-51550111 (-)
CBA/J	MGP_CBAJ_G0015753	protein coding gene	Chr1:55950364-55989160 (-)
DBA/2J	MGP_DBA2J_G0015854	protein coding gene	Chr1:49824328-49856295 (-)
FVB/NJ	MGP_FVBNJ_G0015856	protein coding gene	Chr1:49276718-49309635 (-)
LP/J	MGP_LPJ_G0015925	protein coding gene	Chr1:52775282-52807066 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015876	protein coding gene	Chr1:59004152-59035933 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016449	protein coding gene	Chr1:51757032-51790639 (-)
PWK/PhJ	MGP_PWKPhJ_G0015149	protein coding gene	Chr1:49672292-49705153 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014929	protein coding gene	Chr1:51416296-51444610 (-)
WSB/EiJ	MGP_WSBEiJ_G0015426	protein coding gene	Chr1:51575264-51609134 (-)

Human Ortholog

INPP1, inositol polyphosphate-1-phosphatase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INPP1, inositol polyphosphate-1-phosphatase
Links

HGNC:6071

NCBI Gene ID: 3628

neXtProt AC: NX_P49441

UniProt: P49441
Chr Location

2q32.2; chr2:190343570-190371665 (+) GRCh38

MGI Vertebrate Homology

Inpp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: INPP1
Gene Tree

Inpp1

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Inpp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice homozygous for a targeted allele exhibit decreased susceptibility to bacterial infection.

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

809
Tissues

101
cDNA Data

31
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase inpp1

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All Sequences

54
RefSeq

12
UniProt

4
CCDS

CCDS14947.1

Ensembl

ENSMUSG00000026102 (Evidence)
NCBI Gene

16329

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026102	Ensembl Gene Model \| MGI Sequence Detail	32262	C57BL/6J	± kb
transcript	ENSMUST00000027271	Ensembl \| MGI Sequence Detail	5767	Not Applicable
polypeptide	ENSMUSP00000027271	Ensembl \| MGI Sequence Detail	396	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009044 inositol polyphosphate 1-phosphatase

(term hierarchy)
EC

3.1.3.57
InterPro Domains

IPR050725 CysQ/Inositol Monophosphatase

IPR020550 Inositol monophosphatase, conserved site

IPR000760 Inositol monophosphatase-like

IPR020583 Inositol monophosphatase, metal-binding site

IPR044897 Inositol polyphosphate 1-phosphatase, domain 1
GlyGen

P49442 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 33

Genomic 1

cDNA 32

Microarray probesets 3

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MGD-MRK-28144, MGI:1916781, MGI:2138521

Summaries

All 46

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Inpp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11629	Chr1:52856955-52856982 (-)	-122 bp
Tssr11628	Chr1:52856897-52856937 (-)	-70 bp
Tssr11627	Chr1:52856854-52856895 (-)	-28 bp
Tssr11626	Chr1:52856802-52856852 (-)	20 bp
Tssr11625	Chr1:52856662-52856742 (-)	145 bp
Tssr11624	Chr1:52856600-52856636 (-)	229 bp
Tssr11623	Chr1:52839577-52839607 (-)	17,255 bp
Tssr11622	Chr1:52839547-52839564 (-)	17,291 bp
Tssr11621	Chr1:52838701-52838721 (-)	18,136 bp
Tssr11620	Chr1:52838678-52838692 (-)	18,162 bp
Tssr11619	Chr1:52838644-52838677 (-)	18,186 bp
Tssr11618	Chr1:52834085-52834089 (-)	22,760 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24