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Hes1 Gene Detail
Summary
  • Symbol
    Hes1
  • Name
    hes family bHLH transcription factor 1
  • Synonyms
    bHLHb39, Hry
  • Feature Type
    protein coding gene
  • IDs
    MGI:104853
    NCBI Gene: 15205
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:29883259-29886614 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 21.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104853
 protein coding gene Chr16:29883202-29886614 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022708
 protein coding gene Chr16:27933729-27937142 (+)
A/J MGP_AJ_G0022671
 protein coding gene Chr16:26654836-26658248 (+)
AKR/J MGP_AKRJ_G0022645
 protein coding gene Chr16:27664402-27667814 (+)
BALB/cJ MGP_BALBcJ_G0022675
 protein coding gene Chr16:26835747-26839159 (+)
C3H/HeJ MGP_C3HHeJ_G0022440
 protein coding gene Chr16:27767749-27771161 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023124
 protein coding gene Chr16:28531575-28534987 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020642
 protein coding gene Chr16:27094376-27097842 (+)
CAST/EiJ MGP_CASTEiJ_G0021968
 protein coding gene Chr16:27847388-27850799 (+)
CBA/J MGP_CBAJ_G0022410
 protein coding gene Chr16:29749619-29753037 (+)
DBA/2J MGP_DBA2J_G0022543
 protein coding gene Chr16:26535617-26539029 (+)
FVB/NJ MGP_FVBNJ_G0022518
 protein coding gene Chr16:26505206-26508618 (+)
LP/J MGP_LPJ_G0022610
 protein coding gene Chr16:27750533-27753946 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022537
 protein coding gene Chr16:29287440-29290852 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023136
 protein coding gene Chr16:27622775-27626186 (+)
PWK/PhJ MGP_PWKPhJ_G0021707
 protein coding gene Chr16:26831045-26833497 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021538
 protein coding gene Chr16:27385067-27388473 (+)
WSB/EiJ MGP_WSBEiJ_G0022012
 protein coding gene Chr16:27556897-27560303 (+)



Homology
more
  • Human Ortholog
    HES1, hes family bHLH transcription factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HES1, hes family bHLH transcription factor 1
  • Synonyms
    bHLHb39, HES-1, HHL, HRY
  • Links
    NCBI Gene ID: 3280
    neXtProt AC: NX_Q14469
    UniProt: Q14469

  • Chr Location
    3q29; chr3:194136148-194138732 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 6 alleles in 9 genetic backgrounds
    51 phenotypes from multigenic genotypes
    1 images
    141 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants show anomalous timing in neurogenesis. Homozygotes for a null allele exhibit premature neurogenesis, severe neural tube defects, supernumerary hair cells in the inner ear, increased numbers of pulmonary neuroendocrine cells, and pancreatic hypoplasia. Death occurs in utero or neonatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    210
  • GO References
    49
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1632
  • Tissues
    405
  • cDNA Data
    41
  • Literature Summary
    512
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15205 NCBI Gene Model | MGI Sequence Detail 3356 C57BL/6J ±  kb
    transcript NM_008235 RefSeq | MGI Sequence Detail 1464 ZRU/MplStud  
    polypeptide P35428 UniProt | EBI | MGI Sequence Detail 282 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      Genomic 2
      cDNA 50
      Primer pair 28
      Other 31

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10940, MGD-MRK-28150
    References
    more
    • Summaries
      All 686
      Developmental Gene Expression 512
      Gene Ontology 49
      Phenotypes 141
    • Earliest
      J:43728 Sasai Y, et al., Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 1992 Dec;6(12B):2620-34
    • Latest
      J:359383 Hofstetter KS, et al., Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse. Front Cell Neurosci. 2024;18:1474010
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory