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Ppp1cb Gene Detail
Summary
  • Symbol
    Ppp1cb
  • Name
    protein phosphatase 1 catalytic subunit beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:104871
    NCBI Gene: 19046
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:32616192-32651057 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.33 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    581 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104871
 protein coding gene Chr5:32616187-32674777 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029435
 protein coding gene Chr5:30553271-30615437 (+)
A/J MGP_AJ_G0029401
 protein coding gene Chr5:29539807-29596840 (+)
AKR/J MGP_AKRJ_G0029351
 protein coding gene Chr5:30709310-30771598 (+)
BALB/cJ MGP_BALBcJ_G0029412
 protein coding gene Chr5:30067602-30128903 (+)
C3H/HeJ MGP_C3HHeJ_G0029133
 protein coding gene Chr5:30726047-30786218 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029865
 protein coding gene Chr5:32342653-32415419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027103
 protein coding gene Chr5:27198656-27256609 (+)
CAST/EiJ MGP_CASTEiJ_G0028543
 protein coding gene Chr5:29817560-29878184 (+)
CBA/J MGP_CBAJ_G0029101
 protein coding gene Chr5:33046937-33110534 (+)
DBA/2J MGP_DBA2J_G0029250
 protein coding gene Chr5:29706825-29765491 (+)
FVB/NJ MGP_FVBNJ_G0029208
 protein coding gene Chr5:29124732-29181964 (+)
LP/J MGP_LPJ_G0029335
 protein coding gene Chr5:30984974-31045034 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029237
 protein coding gene Chr5:33839317-33907015 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029899
 protein coding gene Chr5:30210430-30271498 (+)
PWK/PhJ MGP_PWKPhJ_G0028268
 protein coding gene Chr5:28871926-28932071 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028099
 protein coding gene Chr5:29691362-29750383 (+)
WSB/EiJ MGP_WSBEiJ_G0028624
 protein coding gene Chr5:30302601-30362834 (+)



Homology
more
  • Human Ortholog
    PPP1CB, protein phosphatase 1 catalytic subunit beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1CB, protein phosphatase 1 catalytic subunit beta
  • Synonyms
    HEL-S-80p, MP, NSLH2, PP-1B, PP1B, PP1beta, PP1c, PPP1beta, PPP1CD
  • Links
    NCBI Gene ID: 5500
    neXtProt AC: NX_P62140
    UniProt: P62140

  • Chr Location
    2p23.2; chr2:28751604-28802940 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPP1CB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    16
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    6 involving Ppp1cb
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    21 strains or lines available
Homozygous mutation of this gene results in lethality before weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    16
  • cDNA Data
    20
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19046 NCBI Gene Model | MGI Sequence Detail 34866 C57BL/6J ±  kb
transcript NM_172707 RefSeq | MGI Sequence Detail 4024 C57BL/6  
polypeptide P62141 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013103 serine/threonine-protein phosphatase PP1-beta catalytic subunit
    (term hierarchy)
  • EC
    3.1.3.16, 3.1.3.53
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR031675 Serine-threonine protein phosphatase, N-terminal
    IPR050341 Serine/threonine-protein phosphatase PP1 catalytic subunit
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
  • GlyGen
    P62141 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 26
    cDNA 21
    Primer pair 5

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-28170
References
more
  • Summaries
    All 76
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 13
    Phenotypes 31
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory