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Ppp1cc Gene Detail
Summary
  • Symbol
    Ppp1cc
  • Name
    protein phosphatase 1 catalytic subunit gamma
  • Synonyms
    PP1, PP1C gamma, PP1C gamma 1, PP1C gamma 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104872
    NCBI Gene: 19047
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122296341-122313336 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.20 cM, cytoband F-G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104872
 protein coding gene Chr5:122296338-122313336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030043
 protein coding gene Chr5:125775266-125794436 (+)
A/J MGP_AJ_G0030008
 protein coding gene Chr5:120575174-120594320 (+)
AKR/J MGP_AKRJ_G0029944
 protein coding gene Chr5:124442198-124458947 (+)
BALB/cJ MGP_BALBcJ_G0030019
 protein coding gene Chr5:121923210-121940841 (+)
C3H/HeJ MGP_C3HHeJ_G0029736
 protein coding gene Chr5:125059708-125080002 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030472
 protein coding gene Chr5:130609301-130628453 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027698
 protein coding gene Chr5:115190641-115204862 (+)
CAST/EiJ MGP_CASTEiJ_G0029145
 protein coding gene Chr5:124163288-124181972 (+)
CBA/J MGP_CBAJ_G0029706
 protein coding gene Chr5:135728011-135744319 (+)
DBA/2J MGP_DBA2J_G0029856
 protein coding gene Chr5:120629413-120647145 (+)
FVB/NJ MGP_FVBNJ_G0029812
 protein coding gene Chr5:119607451-119626199 (+)
LP/J MGP_LPJ_G0029945
 protein coding gene Chr5:126309993-126332625 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029843
 protein coding gene Chr5:139501038-139521372 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030513
 protein coding gene Chr5:124022577-124041576 (+)
PWK/PhJ MGP_PWKPhJ_G0028859
 protein coding gene Chr5:119397502-119415896 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028696
 protein coding gene Chr5:121747243-121768229 (+)
WSB/EiJ MGP_WSBEiJ_G0029220
 protein coding gene Chr5:124707731-124725266 (+)



Homology
more
  • Human Ortholog
    PPP1CC, protein phosphatase 1 catalytic subunit gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1CC, protein phosphatase 1 catalytic subunit gamma
  • Synonyms
    PP1C, PP-1G, PPP1G
  • Links
    NCBI Gene ID: 5501
    neXtProt AC: NX_P36873
    UniProt: P36873

  • Chr Location
    12q24.11; chr12:110708376-110742939 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 5 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit male infertility due to severely impaired spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    34
  • cDNA Data
    21
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004455 Ensembl Gene Model | MGI Sequence Detail 16996 C57BL/6J ±  kb
    transcript ENSMUST00000086294 Ensembl | MGI Sequence Detail 1442 Not Applicable  
    polypeptide ENSMUSP00000083474 Ensembl | MGI Sequence Detail 337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000013104 serine/threonine-protein phosphatase PP1-gamma catalytic subunit
      (term hierarchy)
    • PDB
      4V0U, 4V0V, 4V0W, 4V0X
    • EC
      3.1.3.16
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR031675 Serine-threonine protein phosphatase, N-terminal
      IPR050341 Serine/threonine-protein phosphatase PP1 catalytic subunit
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    • GlyGen
      P63087 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 21
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28171
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 8
      Gene Ontology 22
      Phenotypes 38
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory