About   Help   FAQ
Ltbr Gene Detail
Summary
  • Symbol
    Ltbr
  • Name
    lymphotoxin B receptor
  • Synonyms
    Ltar, LT beta-R, LTbetaR, LT-beta receptor, Tnfbr, TNFCR, TNFR2-RP, TNF receptor-related protein, TNF-R-III, TNFRrp, Tnfrsf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104875
    NCBI Gene: 17000
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125283534-125290848 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104875
 protein coding gene Chr6:125283534-125291026 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031294
 protein coding gene Chr6:128652765-128662374 (-)
A/J MGP_AJ_G0031265
 protein coding gene Chr6:123794506-123801941 (-)
AKR/J MGP_AKRJ_G0031193
 protein coding gene Chr6:127170219-127177509 (-)
BALB/cJ MGP_BALBcJ_G0031272
 protein coding gene Chr6:123389814-123397328 (-)
C3H/HeJ MGP_C3HHeJ_G0030996
 protein coding gene Chr6:127244188-127251441 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031729
 protein coding gene Chr6:132034294-132054441 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028878
 protein coding gene Chr6:121004731-121011790 (-)
CAST/EiJ MGP_CASTEiJ_G0030377
 protein coding gene Chr6:127456628-127467483 (-)
CBA/J MGP_CBAJ_G0030957
 protein coding gene Chr6:137096307-137103548 (-)
DBA/2J MGP_DBA2J_G0031113
 protein coding gene Chr6:122721022-122728476 (-)
FVB/NJ MGP_FVBNJ_G0031062
 protein coding gene Chr6:121636404-121643664 (-)
LP/J MGP_LPJ_G0031193
 protein coding gene Chr6:128812997-128821126 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031101
 protein coding gene Chr6:141132887-141141724 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031764
 protein coding gene Chr6:127080742-127089158 (-)
PWK/PhJ MGP_PWKPhJ_G0030092
 protein coding gene Chr6:120969731-120977551 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029921
 protein coding gene Chr6:125156731-125166353 (-)
WSB/EiJ MGP_WSBEiJ_G0030462
 protein coding gene Chr6:127453436-127461511 (-)



Homology
more
  • Human Ortholog
    LTBR, lymphotoxin beta receptor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LTBR, lymphotoxin beta receptor
  • Synonyms
    D12S370, LT-BETA-R, TNFCR, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3
  • Links
    NCBI Gene ID: 4055
    neXtProt AC: NX_P36941
    UniProt: P36941

  • Chr Location
    12p13.31; chr12:6375045-6391571 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 8 alleles in 11 genetic backgrounds
    5 phenotypes from multigenic genotypes
    143 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack Peyer's patches, colon-associated lymphoid tissues, and lymph nodes. Mutants also exhibit severely reduced numbers of NK cells and increased susceptibility to Theiler's murine encephalomyelitis virus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    60
  • cDNA Data
    104
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030339 Ensembl Gene Model | MGI Sequence Detail 7315 C57BL/6J ±  kb
    transcript ENSMUST00000032489 Ensembl | MGI Sequence Detail 2107 Not Applicable  
    polypeptide ENSMUSP00000032489 Ensembl | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009976 tumor necrosis factor receptor superfamily member 3
      (term hierarchy)
    • InterPro Domains
      IPR001368 TNFR/NGFR cysteine-rich region
      IPR017349 Tumour necrosis factor receptor 3
      IPR033997 Tumour necrosis factor receptor 3, N-terminal
    • GlyGen
      P50284 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 5
      cDNA 104
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19752, MGD-MRK-28148, MGD-MRK-28175, MGI:104851, MGI:2141385, MGI:893576
    References
    more
    • Summaries
      All 223
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 143
    • Earliest
      J:18011 de Kossodo S, et al., Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. Infect Immun. 1994 Apr;62(4):1414-20
    • Latest
      J:353914 Bessell E, et al., Stromal cell and B cell dialogue potentiates IL-33-enriched lymphoid niches to support eosinophil recruitment and function during type 2 immunity. Cell Rep. 2024 Aug 27;43(8):114620
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory