Psma3 MGI Mouse Gene Detail - MGI:104883 - proteasome subunit alpha 3

Symbol

Psma3
Name

proteasome subunit alpha 3
Synonyms

Lmpc8

Feature Type

protein coding gene
IDs

MGI:104883
NCBI Gene: 19167
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:71021395-71043121 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 29.39 cM
Mapping Data

3 experiments

SNPs within 2kb

721 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104883	protein coding gene	Chr12:71016082-71043121 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019813	protein coding gene	Chr12:70755309-70775327 (+)
A/J	MGP_AJ_G0019771	protein coding gene	Chr12:68109576-68135435 (+)
AKR/J	MGP_AKRJ_G0019747	protein coding gene	Chr12:70149446-70171979 (+)
BALB/cJ	MGP_BALBcJ_G0019751	protein coding gene	Chr12:68567325-68605291 (+)
C3H/HeJ	MGP_C3HHeJ_G0019556	protein coding gene	Chr12:70628993-70650653 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020203	protein coding gene	Chr12:73005515-73028115 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017823	protein coding gene	Chr12:65619533-65639197 (+)
CAST/EiJ	MGP_CASTEiJ_G0019108	protein coding gene	Chr12:65370061-65393231 (+)
CBA/J	MGP_CBAJ_G0019526	protein coding gene	Chr12:75718277-75738653 (+)
DBA/2J	MGP_DBA2J_G0019642	protein coding gene	Chr12:68017512-68038978 (+)
FVB/NJ	MGP_FVBNJ_G0019629	protein coding gene	Chr12:66906973-66927571 (+)
LP/J	MGP_LPJ_G0019714	protein coding gene	Chr12:70731890-70753875 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019668	protein coding gene	Chr12:78965910-78987426 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020238	protein coding gene	Chr12:69644870-69671710 (+)
PWK/PhJ	MGP_PWKPhJ_G0018873	protein coding gene	Chr12:62294735-62318128 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018668	protein coding gene	Chr12:64007936-64029462 (+)
WSB/EiJ	MGP_WSBEiJ_G0019159	protein coding gene	Chr12:70256338-70277812 (+)

Human Ortholog

PSMA3, proteasome 20S subunit alpha 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMA3, proteasome 20S subunit alpha 3
Synonyms

HC8, PSC3
Links

HGNC:9532

NCBI Gene ID: 5684

neXtProt AC: NX_P25788

UniProt: P25788
Chr Location

14q23.1; chr14:58244843-58272012 (+) GRCh38

MGI Vertebrate Homology

Psma3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PSMA3
Gene Tree

Psma3

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

50
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

46
Targeted

2
Genomic Mutations

1 involving Psma3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

15
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

992
Tissues

35
cDNA Data

199
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase psma3

ZFIN psma3

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All Sequences

80
RefSeq

18
UniProt

9
CCDS

CCDS25961.1, CCDS79119.1

Ensembl

ENSMUSG00000060073 (Evidence)
NCBI Gene

19167

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060073	Ensembl Gene Model \| MGI Sequence Detail	21727	C57BL/6J	± kb
transcript	ENSMUST00000160027	Ensembl \| MGI Sequence Detail	2846	Not Applicable
polypeptide	ENSMUSP00000125548	Ensembl \| MGI Sequence Detail	255	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000013362 proteasome subunit alpha type-3

(term hierarchy)
PDB

3UNB, 3UNE, 3UNF, 3UNH, 8YPK, 8YVP
InterPro Domains

IPR029055 Nucleophile aminohydrolases, N-terminal

IPR000426 Proteasome alpha-subunit, N-terminal domain

IPR023332 Proteasome alpha-type subunit

IPR050115 Proteasome subunit alpha

IPR001353 Proteasome, subunit alpha/beta
GlyGen

O70435 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 199

cDNA 199

Microarray probesets 7

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MGD-MRK-11827, MGD-MRK-29036

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 11
Earliest

J:4568 Woodward EC, et al., Chromosomal mapping of the non-MHC linked proteasome genes. J Immunol. 1993;150(8):43A (Abstr.)
Latest

J:256230 Shin SW, et al., Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017 Nov 21;8(1):1643

TSS for Psma3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113701	Chr12:71021430-71021460 (+)	50 bp
Tssr113702	Chr12:71021488-71021500 (+)	99 bp
Tssr113703	Chr12:71021740-71021779 (+)	365 bp
Tssr113704	Chr12:71036755-71036778 (+)	15,372 bp
Tssr113705	Chr12:71037084-71037092 (+)	15,693 bp
Tssr113706	Chr12:71041843-71041844 (+)	20,449 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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