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Tpt1 Gene Detail
Summary
  • Symbol
    Tpt1
  • Name
    tumor protein, translationally-controlled 1
  • Synonyms
    fortilin, TCTP, Trt
  • Feature Type
    protein coding gene
  • IDs
    MGI:104890
    NCBI Gene: 22070
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:76082771-76085743 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 40.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104890
 protein coding gene Chr14:76082533-76085965 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021575
 protein coding gene Chr14:70710076-70713357 (+)
A/J MGP_AJ_G0021533
 protein coding gene Chr14:69105128-69108763 (+)
AKR/J MGP_AKRJ_G0021510
 protein coding gene Chr14:71166664-71172278 (+)
BALB/cJ MGP_BALBcJ_G0021540
 protein coding gene Chr14:68903945-68907307 (+)
C3H/HeJ MGP_C3HHeJ_G0021317
 protein coding gene Chr14:70887080-70891636 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021980
 protein coding gene Chr14:73812646-73813283 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019518
 protein coding gene Chr14:66723031-66727125 (+)
CAST/EiJ MGP_CASTEiJ_G0020834
 protein coding gene Chr14:67561021-67563971 (+)
CBA/J MGP_CBAJ_G0021285
 protein coding gene Chr14:76163796-76170645 (+)
DBA/2J MGP_DBA2J_G0021408
 protein coding gene Chr14:68513319-68516310 (+)
FVB/NJ MGP_FVBNJ_G0021386
 protein coding gene Chr14:67849577-67853112 (+)
LP/J MGP_LPJ_G0021478
 protein coding gene Chr14:71874013-71877338 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021413
 protein coding gene Chr14:74909366-74916625 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022003
 protein coding gene Chr14:70440637-70448429 (+)
PWK/PhJ MGP_PWKPhJ_G0020577
 protein coding gene Chr14:65252101-65255515 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020414
 protein coding gene Chr14:66412680-66416880 (+)
WSB/EiJ MGP_WSBEiJ_G0020887
 protein coding gene Chr14:70782825-70787155 (+)



Homology
more
  • Human Ortholog
    TPT1, tumor protein, translationally-controlled 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPT1, tumor protein, translationally-controlled 1
  • Synonyms
    HRF, p02, p23, TCTP
  • Links
    NCBI Gene ID: 7178
    neXtProt AC: NX_P13693
    UniProt: P13693

  • Chr Location
    13q14.13; chr13:45333471-45341284 (-)  GRCh38
  • Human Ortholog
    TPT1P8, TPT1 pseudogene 8
  • Synonyms
    FKSG2
  • Links
    NCBI Gene ID: 59347
    UniProt: Q9HAU6

  • Chr Location
    8p11.23; chr8:36888370-36889530 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die prior to embryo turning due to defects in embryogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    6
  • cDNA Data
    997
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22070 NCBI Gene Model | MGI Sequence Detail 2973 C57BL/6J ±  kb
    transcript NM_009429 RefSeq | MGI Sequence Detail 819 C57BL/6  
    polypeptide P63028 UniProt | EBI | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016596 translationally-controlled tumor protein
      (term hierarchy)
    • PDB
      5O9K
    • InterPro Domains
      IPR011057 Mss4-like superfamily
      IPR011323 Mss4/translationally controlled tumour-associated TCTP
      IPR018105 Translationally controlled tumour protein
      IPR018103 Translationally controlled tumour protein, conserved site
      IPR034737 Translationally controlled tumour protein (TCTP) domain
    • GlyGen
      P63028 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 999
      cDNA 997
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-29043
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:30851 Chitpatima ST, et al., Nucleotide sequence of a major messenger RNA for a 21 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res. 1988 Mar 25;16(5):2350
    • Latest
      J:329345 Morimoto Y, et al., TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF). Neurochem Res. 2022 Sep;47(9):2741-2756
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory