Srsf9 MGI Mouse Gene Detail - MGI:104896 - serine and arginine-rich splicing factor 9

Symbol

Srsf9
Name

serine and arginine-rich splicing factor 9
Synonyms

2610029M16Rik, Sfrs9, SRp30c

Feature Type

protein coding gene
IDs

MGI:104896
NCBI Gene: 108014
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:115465236-115471139 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 56.05 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

195 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104896	protein coding gene	Chr5:115465236-115471139 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029965	protein coding gene	Chr5:118175923-118184032 (+)
A/J	MGP_AJ_G0029930	protein coding gene	Chr5:113492145-113498126 (+)
AKR/J	MGP_AKRJ_G0029868	protein coding gene	Chr5:117132637-117139620 (+)
BALB/cJ	MGP_BALBcJ_G0029941	protein coding gene	Chr5:114888771-114894666 (+)
C3H/HeJ	MGP_C3HHeJ_G0029660	protein coding gene	Chr5:117631650-117638748 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030395	protein coding gene	Chr5:122741740-122747919 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027622	protein coding gene	Chr5:108268088-108273922 (+)
CAST/EiJ	MGP_CASTEiJ_G0029069	protein coding gene	Chr5:116555483-116562264 (+)
CBA/J	MGP_CBAJ_G0029628	protein coding gene	Chr5:127458254-127464098 (+)
DBA/2J	MGP_DBA2J_G0029778	protein coding gene	Chr5:113566048-113571933 (+)
FVB/NJ	MGP_FVBNJ_G0029734	protein coding gene	Chr5:112384308-112390160 (+)
LP/J	MGP_LPJ_G0029866	protein coding gene	Chr5:118751296-118758340 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029765	protein coding gene	Chr5:131772055-131779096 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030436	protein coding gene	Chr5:116591714-116598808 (+)
PWK/PhJ	MGP_PWKPhJ_G0028782	protein coding gene	Chr5:112227975-112234128 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028620	protein coding gene	Chr5:114150431-114156321 (+)
WSB/EiJ	MGP_WSBEiJ_G0029144	protein coding gene	Chr5:117190030-117197266 (+)

Human Ortholog

SRSF9, serine and arginine rich splicing factor 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRSF9, serine and arginine rich splicing factor 9
Synonyms

SFRS9, SRp30c
Links

HGNC:10791

NCBI Gene ID: 8683

neXtProt AC: NX_Q13242

UniProt: Q13242
Chr Location

12q24.31; chr12:120461672-120495946 (-) GRCh38

MGI Vertebrate Homology

Srsf9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRSF9
Gene Tree

Srsf9

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Srsf9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

25
cDNA Data

62
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srsf9

ZFIN srsf9

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All Sequences

43
RefSeq

3
UniProt

4
CCDS

CCDS19587.1

Ensembl

ENSMUSG00000029538 (Evidence)
NCBI Gene

108014

			Length	Strain/Species	Flank
genomic	108014	NCBI Gene Model \| MGI Sequence Detail	5904	C57BL/6J	± kb
transcript	NR_036616	RefSeq \| MGI Sequence Detail	1252	C57BL/6
polypeptide	Q9D0B0	UniProt \| EBI \| MGI Sequence Detail	222	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014766 serine/arginine-rich splicing factor 9

(term hierarchy)
PDB

1WG4
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR050374 RRT5/SRSF/Splicing Factor SR

IPR034503 SRSF9, RNA recognition motif 1

IPR034995 SRSF9, RNA recognition motif 2

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All nucleic 65

Genomic 1

cDNA 63

Primer pair 1

Microarray probesets 3

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MGD-MRK-29049, MGI:1913703

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:347878 Li Z, et al., FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility. Elife. 2024 Mar 12;12

TSS for Srsf9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48214	Chr5:115465118-115465129 (+)	-112 bp
Tssr48215	Chr5:115465184-115465258 (+)	-15 bp
Tssr48216	Chr5:115465260-115465326 (+)	57 bp
Tssr48217	Chr5:115465333-115465342 (+)	102 bp
Tssr48218	Chr5:115465703-115465736 (+)	484 bp
Tssr48219	Chr5:115465782-115465793 (+)	552 bp
Tssr48220	Chr5:115470780-115470852 (+)	5,580 bp
Tssr48221	Chr5:115470917-115470931 (+)	5,688 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24