Nup88 MGI Mouse Gene Detail - MGI:104900

Symbol

Nup88
Name

nucleoporin 88
Synonyms

Nup84, Prei2

Feature Type

protein coding gene
IDs

MGI:104900
NCBI Gene: 19069
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:70833884-70860799 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.21 cM
Mapping Data

2 experiments

SNPs within 2kb

170 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104900	protein coding gene	Chr11:70833884-70860799 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018618	protein coding gene	Chr11:71517296-71544242 (-)
A/J	MGP_AJ_G0018586	protein coding gene	Chr11:68799316-68825977 (-)
AKR/J	MGP_AKRJ_G0018555	protein coding gene	Chr11:70871940-70900447 (-)
BALB/cJ	MGP_BALBcJ_G0018558	protein coding gene	Chr11:69109604-69136210 (-)
C3H/HeJ	MGP_C3HHeJ_G0018371	protein coding gene	Chr11:70901667-70928295 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019009	protein coding gene	Chr11:73686983-73713606 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016654	protein coding gene	Chr11:65706762-65730925 (-)
CAST/EiJ	MGP_CASTEiJ_G0017926	protein coding gene	Chr11:71176765-71205161 (-)
CBA/J	MGP_CBAJ_G0018343	protein coding gene	Chr11:77007482-77034092 (-)
DBA/2J	MGP_DBA2J_G0018453	protein coding gene	Chr11:68378800-68405888 (-)
FVB/NJ	MGP_FVBNJ_G0018443	protein coding gene	Chr11:68022595-68049113 (-)
LP/J	MGP_LPJ_G0018523	protein coding gene	Chr11:72097404-72123975 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018466	protein coding gene	Chr11:77544105-77571655 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019051	protein coding gene	Chr11:71130738-71158335 (-)
PWK/PhJ	MGP_PWKPhJ_G0017700	protein coding gene	Chr11:69029918-69057450 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017490	protein coding gene	Chr11:70942734-70967067 (-)
WSB/EiJ	MGP_WSBEiJ_G0017980	protein coding gene	Chr11:70795063-70821633 (-)

Human Ortholog

NUP88, nucleoporin 88

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUP88, nucleoporin 88
Synonyms

FADS4
Links

HGNC:8067

NCBI Gene ID: 4927

neXtProt AC: NX_Q99567

UniProt: Q99567
Chr Location

17p13.2; chr17:5359668-5420164 (-) GRCh38

MGI Vertebrate Homology

Nup88 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUP88
Gene Tree

Nup88

Diseases

1 with human NUP88 associations

				Human Disease	Mouse Models
				fetal akinesia deformation sequence syndrome 4 IDs fetal akinesia deformation sequence syndrome 4 DOID:0111379 OMIM:618393

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 2 alleles in 1 genetic background
2 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

24
Targeted

5
Genomic Mutations

2 involving Nup88
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

34
cDNA Data

181
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nup88

ZFIN nup88

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All Sequences

65
RefSeq

7
UniProt

6
CCDS

CCDS36206.1, CCDS36207.1, CCDS70233.1

Ensembl

ENSMUSG00000040667 (Evidence)
NCBI Gene

19069

			Length	Strain/Species	Flank
genomic	19069	NCBI Gene Model \| MGI Sequence Detail	26916	C57BL/6J	± kb
transcript	NR_075087	RefSeq \| MGI Sequence Detail	2792	ZRU/MplStud
polypeptide	Q8CEC0	UniProt \| EBI \| MGI Sequence Detail	753	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000011524 nuclear pore complex protein Nup88

(term hierarchy)
InterPro Domains

IPR019321 Nucleoporin Nup88

IPR037700 Nucleoporin NUP88/NUP82
GlyGen

Q8CEC0 1 site, 1 O-linked glycan (1 site)

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All nucleic 188

Genomic 2

cDNA 184

Primer pair 2

Microarray probesets 3

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MGD-MRK-29053

Summaries

All 52

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nup88:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109047	Chr11:70861919-70861930 (-)	-1,126 bp
Tssr109046	Chr11:70861902-70861913 (-)	-1,109 bp
Tssr109045	Chr11:70861588-70861607 (-)	-799 bp
Tssr109044	Chr11:70861548-70861555 (-)	-753 bp
Tssr109043	Chr11:70860779-70860804 (-)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24