Gpc4 MGI Mouse Gene Detail - MGI:104902

Symbol

Gpc4
Name

glypican 4
Synonyms

9530073D23Rik, K-glypican

Feature Type

protein coding gene
IDs

MGI:104902
NCBI Gene: 14735
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:51141898-51254129 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 28.33 cM
Mapping Data

7 experiments

SNPs within 2kb

1968 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104902	protein coding gene	ChrX:51139884-51254129 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035715	protein coding gene	ChrX:47250054-47366966 (-)
A/J	MGP_AJ_G0035698	protein coding gene	ChrX:47106298-47230274 (-)
AKR/J	MGP_AKRJ_G0035618	protein coding gene	ChrX:48404580-48521353 (-)
BALB/cJ	MGP_BALBcJ_G0035684	protein coding gene	ChrX:46658039-46770459 (-)
C3H/HeJ	MGP_C3HHeJ_G0035388	protein coding gene	ChrX:47499399-47614839 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036214	protein coding gene	ChrX:48363969-48484076 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033065	protein coding gene	ChrX:44580375-44692994 (-)
CAST/EiJ	MGP_CASTEiJ_G0034679	protein coding gene	ChrX:34944499-35062772 (-)
CBA/J	MGP_CBAJ_G0035362	protein coding gene	ChrX:49707924-49828918 (-)
DBA/2J	MGP_DBA2J_G0035517	protein coding gene	ChrX:46907829-47020770 (-)
FVB/NJ	MGP_FVBNJ_G0035465	protein coding gene	ChrX:46615139-46728051 (-)
LP/J	MGP_LPJ_G0035604	protein coding gene	ChrX:47558345-47676372 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035504	protein coding gene	ChrX:51278320-51398145 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036231	protein coding gene	ChrX:47129599-47243905 (-)
PWK/PhJ	MGP_PWKPhJ_G0034378	protein coding gene	ChrX:34433729-34548899 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034223	protein coding gene	ChrX:35732284-35845353 (-)
WSB/EiJ	MGP_WSBEiJ_G0034823	protein coding gene	ChrX:46691677-46809116 (-)

Human Ortholog

GPC4, glypican 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPC4, glypican 4
Synonyms

K-glypican, KPTS
Links

HGNC:4452

NCBI Gene ID: 2239

neXtProt AC: NX_O75487

UniProt: O75487
Chr Location

Xq26.2; chrX:133300103-133415489 (-) GRCh38

MGI Vertebrate Homology

Gpc4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPC4
Gene Tree

Gpc4

Diseases

1 with human GPC4 associations

				Human Disease	Mouse Models
				Keipert syndrome IDs Keipert syndrome DOID:0111842 MESH:C538337 NCI:C186306 OMIM:301026 ORDO:2662 UMLS_CUI:C1850627

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

2
Gene trapped

10
Targeted

7
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice hemizygous for a null allele exhibit signs of anemia.

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All GO Annotations

25
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1265
Tissues

168
cDNA Data

23
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GPC4

Xenbase gpc4

ZFIN gpc4

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All Sequences

44
RefSeq

4
UniProt

1
CCDS

CCDS30124.1

Ensembl

ENSMUSG00000031119 (Evidence)
NCBI Gene

14735

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031119	Ensembl Gene Model \| MGI Sequence Detail	112232	C57BL/6J	± kb
transcript	ENSMUST00000033450	Ensembl \| MGI Sequence Detail	2651	Not Applicable
polypeptide	ENSMUSP00000033450	Ensembl \| MGI Sequence Detail	557	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008166 glypican-4

(term hierarchy)
InterPro Domains

IPR001863 Glypican

IPR019803 Glypican, conserved site
GlyGen

P51655 4 sites

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All nucleic 30

cDNA 23

Primer pair 6

Other 1

Microarray probesets 5

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MGD-MRK-29056, MGI:1925872, MGI:2147881, MGI:2147905, MGI:2152785

Summaries

All 86

Developmental Gene Expression 23

Gene Ontology 10

Phenotypes 22
Earliest

J:59268 Williams BO, et al., Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J. 1994 Sep 15;13(18):4251-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163356	ChrX:51254222-51254239 (-)	-102 bp
Tssr163355	ChrX:51254189-51254212 (-)	-72 bp
Tssr163354	ChrX:51254146-51254157 (-)	-23 bp
Tssr163353	ChrX:51142321-51142325 (-)	111,806 bp
Tssr163352	ChrX:51142033-51142044 (-)	112,090 bp
Tssr163351	ChrX:51141978-51142002 (-)	112,139 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24