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Gpc3 Gene Detail
Summary
  • Symbol
    Gpc3
  • Name
    glypican 3
  • Synonyms
    OCI-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:104903
    NCBI Gene: 14734
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:51361303-51702827 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 28.74 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6153 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104903
 protein coding gene ChrX:51361303-51702851 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035716
 protein coding gene ChrX:47484518-47825911 (-)
A/J MGP_AJ_G0035699
 protein coding gene ChrX:47337642-47682041 (-)
AKR/J MGP_AKRJ_G0035619
 protein coding gene ChrX:48634349-48980470 (-)
BALB/cJ MGP_BALBcJ_G0035685
 protein coding gene ChrX:46879887-47220771 (-)
C3H/HeJ MGP_C3HHeJ_G0035389
 protein coding gene ChrX:47727909-48076348 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036215
 protein coding gene ChrX:48605913-48952038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033066
 protein coding gene ChrX:44799028-45137318 (-)
CAST/EiJ MGP_CASTEiJ_G0034680
 protein coding gene ChrX:35174322-35521259 (-)
CBA/J MGP_CBAJ_G0035363
 protein coding gene ChrX:49956719-50315074 (-)
DBA/2J MGP_DBA2J_G0035518
 protein coding gene ChrX:47128565-47468207 (-)
FVB/NJ MGP_FVBNJ_G0035466
 protein coding gene ChrX:46842826-47186075 (-)
LP/J MGP_LPJ_G0035605
 protein coding gene ChrX:47803124-48149183 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035505
 protein coding gene ChrX:51518580-51859591 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036232
 protein coding gene ChrX:47358981-47707206 (-)
PWK/PhJ MGP_PWKPhJ_G0034379
 protein coding gene ChrX:34669052-35010502 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034224
 protein coding gene ChrX:35963463-36312777 (-)
WSB/EiJ MGP_WSBEiJ_G0034824
 protein coding gene ChrX:46923437-47266218 (-)



Homology
more
  • Human Ortholog
    GPC3, glypican 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPC3, glypican 3
  • Synonyms
    DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1
  • Links
    NCBI Gene ID: 2719
    neXtProt AC: NX_P51654
    UniProt: P51654

  • Chr Location
    Xq26.2; chrX:133535745-133987100 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gpc3 mouse models; 2 with human GPC3 associations

Human Disease Mouse Models
      
IDs
 View 8 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 4 alleles in 5 genetic backgrounds
    19 phenotypes from multigenic genotypes
    4 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A gene trap mutation exibits neonatal lethality, embryonic overgrowth and kidney cysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1066
  • Tissues
    134
  • cDNA Data
    134
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055653 Ensembl Gene Model | MGI Sequence Detail 341525 C57BL/6J ±  kb
    transcript ENSMUST00000069360 Ensembl | MGI Sequence Detail 2216 Not Applicable  
    polypeptide ENSMUSP00000064131 Ensembl | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 144
      cDNA 135
      Primer pair 8
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-29057
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 44
      Diseases 3
      Gene Ontology 21
      Phenotypes 21
    • Earliest
      J:28429 Watanabe K, et al., K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995 Sep;130(5):1207-18
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory