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Ptk2b Gene Detail
Summary
  • Symbol
    Ptk2b
  • Name
    PTK2 protein tyrosine kinase 2 beta
  • Synonyms
    CAKbeta, calcium-dependent tyrosine kinase, cellular adhesion kinase beta, E430023O05Rik, proline-rich tyrosine kinase 2, PYK2, Raftk, related adhesion focal tyrosine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:104908
    NCBI Gene: 19229
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66390706-66518501 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3372 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104908
 protein coding gene Chr14:66390706-66518549 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021493
 protein coding gene Chr14:60810929-60950653 (-)
A/J MGP_AJ_G0021452
 protein coding gene Chr14:59379199-59503229 (-)
AKR/J MGP_AKRJ_G0021428
 protein coding gene Chr14:61443078-61576534 (-)
BALB/cJ MGP_BALBcJ_G0021458
 protein coding gene Chr14:59332245-59469255 (-)
C3H/HeJ MGP_C3HHeJ_G0021235
 protein coding gene Chr14:61121621-61259152 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021897
 protein coding gene Chr14:63605337-63761934 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019437
 protein coding gene Chr14:57309444-57434721 (-)
CAST/EiJ MGP_CASTEiJ_G0020752
 protein coding gene Chr14:57601343-57733666 (-)
CBA/J MGP_CBAJ_G0021202
 protein coding gene Chr14:65544530-65697236 (-)
DBA/2J MGP_DBA2J_G0021325
 protein coding gene Chr14:59027416-59157046 (-)
FVB/NJ MGP_FVBNJ_G0021304
 protein coding gene Chr14:58437278-58568010 (-)
LP/J MGP_LPJ_G0021400
 protein coding gene Chr14:61854991-61997117 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021333
 protein coding gene Chr14:64619395-64749787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021920
 protein coding gene Chr14:60636924-60773820 (-)
PWK/PhJ MGP_PWKPhJ_G0020496
 protein coding gene Chr14:55759020-55889847 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020329
 protein coding gene Chr14:56604783-56734956 (-)
WSB/EiJ MGP_WSBEiJ_G0020805
 protein coding gene Chr14:60942524-61074870 (-)



Homology
more
  • Human Ortholog
    PTK2B, protein tyrosine kinase 2 beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTK2B, protein tyrosine kinase 2 beta
  • Synonyms
    CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
  • Links
    NCBI Gene ID: 2185
    neXtProt AC: NX_Q14289
    UniProt: Q14289

  • Chr Location
    8p21.2; chr8:27310506-27459391 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PTK2B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 3 genetic backgrounds
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show alterations in endothelial nitric oxide synthase-mediated vascular function and angiogenic responses. Mice homozygous for a second knock-out allele exhibit multiple defects in macrophage migration and function. Homozygous KO also results in increased female fecundity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    213
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    26
  • cDNA Data
    47
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059456 Ensembl Gene Model | MGI Sequence Detail 127796 C57BL/6J ±  kb
    transcript ENSMUST00000022622 Ensembl | MGI Sequence Detail 4034 Not Applicable  
    polypeptide ENSMUSP00000022622 Ensembl | MGI Sequence Detail 1009 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 2
      cDNA 47
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-29062, MGI:2444305
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 12
      Gene Ontology 26
      Phenotypes 52
    • Earliest
      J:29773 Avraham S, et al., Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem. 1995 Nov 17;270(46):27742-51
    • Latest
      J:358523 Zhou G, et al., PTK2B regulates immune responses of neutrophils and protects mucosal inflammation in ulcerative colitis. FASEB J. 2023 Jul;37(7):e22967
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory