Il1rap MGI Mouse Gene Detail - MGI:104975 - interleukin 1 receptor accessory protein

Symbol

Il1rap
Name

interleukin 1 receptor accessory protein
Synonyms

6430709H04Rik, IL-1R AcP, IL-1RAcP

Feature Type

protein coding gene
IDs

MGI:104975
NCBI Gene: 16180
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:26400454-26548867 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 18.21 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

4596 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104975	protein coding gene	Chr16:26400259-26548878 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022696	protein coding gene	Chr16:24324128-24473928 (+)
A/J	MGP_AJ_G0022658	protein coding gene	Chr16:23180397-23327516 (+)
AKR/J	MGP_AKRJ_G0022632	protein coding gene	Chr16:24125977-24274288 (+)
BALB/cJ	MGP_BALBcJ_G0022663	protein coding gene	Chr16:23381415-23528814 (+)
C3H/HeJ	MGP_C3HHeJ_G0022427	protein coding gene	Chr16:24218614-24364376 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023112	protein coding gene	Chr16:24848850-24991859 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020630	protein coding gene	Chr16:23741569-23885893 (+)
CAST/EiJ	MGP_CASTEiJ_G0021956	protein coding gene	Chr16:24260265-24408868 (+)
CBA/J	MGP_CBAJ_G0022398	protein coding gene	Chr16:25922868-26090569 (+)
DBA/2J	MGP_DBA2J_G0022530	protein coding gene	Chr16:23120839-23268084 (+)
FVB/NJ	MGP_FVBNJ_G0022506	protein coding gene	Chr16:23103789-23251643 (+)
LP/J	MGP_LPJ_G0022598	protein coding gene	Chr16:24103888-24260645 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022525	protein coding gene	Chr16:25342511-25497681 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023124	protein coding gene	Chr16:24077498-24228338 (+)
PWK/PhJ	MGP_PWKPhJ_G0021695	protein coding gene	Chr16:23410572-23557922 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021526	protein coding gene	Chr16:23828630-23977057 (+)
WSB/EiJ	MGP_WSBEiJ_G0022000	protein coding gene	Chr16:24009741-24161569 (+)

Human Ortholog

IL1RAP, interleukin 1 receptor accessory protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL1RAP, interleukin 1 receptor accessory protein
Synonyms

C3orf13, IL1R3, IL-1RAcP
Links

HGNC:5995

NCBI Gene ID: 3556

neXtProt AC: NX_Q9NPH3

UniProt: Q9NPH3
Chr Location

3q28; chr3:190514051-190659750 (+) GRCh38

MGI Vertebrate Homology

Il1rap stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL1RAP
Gene Tree

Il1rap

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

9
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile and grossly normal but show no biological response to IL-1.

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All GO Annotations

43
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

783
Tissues

46
cDNA Data

64
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il1rap

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All Sequences

67
RefSeq

13
UniProt

6
CCDS

CCDS28089.1, CCDS49814.1, CCDS49815.1, CCDS57023.1

Ensembl

ENSMUSG00000022514 (Evidence)
NCBI Gene

16180

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022514	Ensembl Gene Model \| MGI Sequence Detail	148414	C57BL/6J	± kb
transcript	ENSMUST00000096129	Ensembl \| MGI Sequence Detail	4438	Not Applicable
polypeptide	ENSMUSP00000093843	Ensembl \| MGI Sequence Detail	685	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008991 interleukin-1 receptor accessory protein

(term hierarchy)
PDB

4YFD, 5VI4
EC

3.2.2.6
InterPro Domains

IPR041416 IL-1Ra-like, immunoglobulin domain

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR015621 Interleukin-1 receptor family

IPR004074 Interleukin-1 receptor type I/II

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
GlyGen

Q61730 8 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 67

cDNA 65

Primer pair 1

Other 1

Microarray probesets 9

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MGD-MRK-31048, MGI:2146394, MGI:2146602, MGI:2441718

Summaries

All 77

Developmental Gene Expression 6

Gene Ontology 14

Phenotypes 29
Earliest

J:25951 Greenfeder SA, et al., Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J Biol Chem. 1995 Jun 9;270(23):13757-65
Latest

J:358078 Tongmuang N, et al., UL56 Is Essential for Herpes Simplex Virus-1 Virulence In Vivo but Is Dispensable for Induction of Host-Protective Immunity. Vaccines (Basel). 2024 Jul 25;12(8)

TSS for Il1rap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137816	Chr16:26400475-26400513 (+)	40 bp
Tssr137817	Chr16:26401090-26401094 (+)	638 bp
Tssr137818	Chr16:26459826-26459830 (+)	59,374 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24