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Cyp7b1 Gene Detail
Summary
  • Symbol
    Cyp7b1
  • Name
    cytochrome P450, family 7, subfamily b, polypeptide 1
  • Synonyms
    D3Ertd552e, hct-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104978
    NCBI Gene: 13123
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:18126114-18297502 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 4.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4977 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104978
 protein coding gene Chr3:18126108-18298054 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027088
 protein coding gene Chr3:15244626-15417965 (-)
A/J MGP_AJ_G0027049
 protein coding gene Chr3:15167374-15344768 (-)
AKR/J MGP_AKRJ_G0027018
 protein coding gene Chr3:15264289-15454828 (-)
BALB/cJ MGP_BALBcJ_G0027061
 protein coding gene Chr3:14944457-15118548 (-)
C3H/HeJ MGP_C3HHeJ_G0026801
 protein coding gene Chr3:15349215-15528873 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027505
 protein coding gene Chr3:16256974-16448362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024867
 protein coding gene Chr3:13382387-13551495 (-)
CAST/EiJ MGP_CASTEiJ_G0026257
 protein coding gene Chr3:15287771-15459853 (-)
CBA/J MGP_CBAJ_G0026779
 protein coding gene Chr3:16574937-16766609 (-)
DBA/2J MGP_DBA2J_G0026913
 protein coding gene Chr3:14771992-14950967 (-)
FVB/NJ MGP_FVBNJ_G0026882
 protein coding gene Chr3:14469197-14640629 (-)
LP/J MGP_LPJ_G0027025
 protein coding gene Chr3:15868120-16044765 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026902
 protein coding gene Chr3:18577050-18774158 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027564
 protein coding gene Chr3:15041262-15218006 (-)
PWK/PhJ MGP_PWKPhJ_G0025990
 protein coding gene Chr3:14513884-14690875 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025797
 protein coding gene Chr3:14880055-15062611 (-)
WSB/EiJ MGP_WSBEiJ_G0026330
 protein coding gene Chr3:15113925-15294821 (-)



Homology
more
  • Human Ortholog
    CYP7B1, cytochrome P450 family 7 subfamily B member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP7B1, cytochrome P450 family 7 subfamily B member 1
  • Synonyms
    CBAS3, CP7B, SPG5A
  • Links
    NCBI Gene ID: 9420
    neXtProt AC: NX_O75881
    UniProt: O75881

  • Chr Location
    8q12.3; chr8:64586575-64798737 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CYP7B1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show significantly increased levels of 25- and 27-hydroxycholesterol, and reduced IgA levels. Female mice homozygous for a reporter allele display early onset of puberty and early ovarian failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    220
  • cDNA Data
    32
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039519 Ensembl Gene Model | MGI Sequence Detail 171389 C57BL/6J ±  kb
    transcript ENSMUST00000035625 Ensembl | MGI Sequence Detail 2166 Not Applicable  
    polypeptide ENSMUSP00000037487 Ensembl | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 32
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-31051, MGI:1261887, MGI:2139981
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 11
      Phenotypes 35
    • Earliest
      J:30123 Stapleton G, et al., A novel cytochrome P450 expressed primarily in brain. J Biol Chem. 1995 Dec 15;270(50):29739-45
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory