Cnn1 MGI Mouse Gene Detail - MGI:104979

Symbol

Cnn1
Name

calponin 1
Synonyms

calponin h1, CN, CnnI

Feature Type

protein coding gene
IDs

MGI:104979
NCBI Gene: 12797
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:22010501-22020517 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 8.30 cM, cytoband A2-A4
Mapping Data

1 experiment

SNPs within 2kb

392 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104979	protein coding gene	Chr9:22010501-22020926 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034477	protein coding gene	Chr9:19389166-19399895 (+)
A/J	MGP_AJ_G0034455	protein coding gene	Chr9:19005070-19016622 (+)
AKR/J	MGP_AKRJ_G0034381	protein coding gene	Chr9:19370287-19380636 (+)
BALB/cJ	MGP_BALBcJ_G0034446	protein coding gene	Chr9:18885254-18895791 (+)
C3H/HeJ	MGP_C3HHeJ_G0034158	protein coding gene	Chr9:19684331-19694586 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034967	protein coding gene	Chr9:20160962-20171496 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031897	protein coding gene	Chr9:18103941-18114452 (+)
CAST/EiJ	MGP_CASTEiJ_G0033481	protein coding gene	Chr9:19520813-19534490 (+)
CBA/J	MGP_CBAJ_G0034131	protein coding gene	Chr9:20927051-20956831 (+)
DBA/2J	MGP_DBA2J_G0034289	protein coding gene	Chr9:18967692-18977945 (+)
FVB/NJ	MGP_FVBNJ_G0034232	protein coding gene	Chr9:18521358-18531680 (+)
LP/J	MGP_LPJ_G0034375	protein coding gene	Chr9:19547188-19557510 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034276	protein coding gene	Chr9:22483769-22494091 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034987	protein coding gene	Chr9:19345092-19358123 (+)
PWK/PhJ	MGP_PWKPhJ_G0033186	protein coding gene	Chr9:18975960-18986499 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033020	protein coding gene	Chr9:19372847-19383072 (+)
WSB/EiJ	MGP_WSBEiJ_G0033596	protein coding gene	Chr9:19079278-19091575 (+)

Human Ortholog

CNN1, calponin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNN1, calponin 1
Synonyms

HEL-S-14, Sm-Calp, SMCC
Links

HGNC:2155

NCBI Gene ID: 1264

neXtProt AC: NX_P51911

UniProt: P51911
Chr Location

19p13.2; chr19:11538767-11550323 (+) GRCh38

MGI Vertebrate Homology

Cnn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CNN1
Gene Tree

Cnn1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for an allele lacking exons 5-7 exhibit accelerated cartilage formation and ossification. As adults mutant animals have increased width of the long bones and accelerated bone fracture repair. Mice homozygous for an allele lacking intron 1exhibit preweaning lethality.

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

906
Tissues

80
cDNA Data

88
Literature Summary

68

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnn1

ZFIN cnn1a, cnn1b

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All Sequences

57
RefSeq

6
UniProt

6
CCDS

CCDS22921.1

Ensembl

ENSMUSG00000001349 (Evidence)
NCBI Gene

12797

			Length	Strain/Species	Flank
genomic	12797	NCBI Gene Model \| MGI Sequence Detail	10017	C57BL/6J	± kb
transcript	NM_009922	RefSeq \| MGI Sequence Detail	1987	C57BL/6
polypeptide	Q08091	UniProt \| EBI \| MGI Sequence Detail	297	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005640 calponin-1

(term hierarchy)
InterPro Domains

IPR001715 Calponin homology domain

IPR050606 Calponin-like

IPR001997 Calponin/LIMCH1

IPR000557 Calponin repeat

IPR036872 CH domain superfamily

IPR003096 Smooth muscle protein/calponin
GlyGen

Q08091 1 site, 1 N-linked glycan (1 site)

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All nucleic 102

Genomic 6

cDNA 89

Primer pair 4

Other 3

Microarray probesets 3

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MGD-MRK-31052

Summaries

All 109

Developmental Gene Expression 68

Gene Ontology 7

Phenotypes 13
Earliest

J:30866 Strasser P, et al., Mammalian calponin. Identification and expression of genetic variants. FEBS Lett. 1993 Sep 6;330(1):13-8
Latest

J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584

TSS for Cnn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84069	Chr9:22010567-22010583 (+)	74 bp
Tssr84070	Chr9:22011547-22011561 (+)	1,053 bp
Tssr84071	Chr9:22011565-22011580 (+)	1,072 bp
Tssr84072	Chr9:22012371-22012429 (+)	1,899 bp
Tssr84073	Chr9:22012430-22012448 (+)	1,938 bp
Tssr84074	Chr9:22012486-22012502 (+)	1,993 bp
Tssr84075	Chr9:22012503-22012518 (+)	2,010 bp
Tssr2807	Chr9:22016706-22016719 (+)	6,212 bp
Tssr84076	Chr9:22019396-22019409 (+)	8,902 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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