Gclm MGI Mouse Gene Detail - MGI:104995 - glutamate-cysteine ligase, modifier subunit

Symbol

Gclm
Name

glutamate-cysteine ligase, modifier subunit
Synonyms

Gcmc, Glclr

Feature Type

protein coding gene
IDs

MGI:104995
NCBI Gene: 14630
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr3:122039206-122060864 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 52.94 cM, cytoband H1-3
Mapping Data

3 experiments

SNPs within 2kb

469 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104995	protein coding gene	Chr3:122039206-122064381 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027837	protein coding gene	Chr3:124497241-124520940 (+)
A/J	MGP_AJ_G0027795	protein coding gene	Chr3:120332054-120352237 (+)
AKR/J	MGP_AKRJ_G0027761	protein coding gene	Chr3:123399449-123420277 (+)
BALB/cJ	MGP_BALBcJ_G0027807	protein coding gene	Chr3:120140384-120161224 (+)
C3H/HeJ	MGP_C3HHeJ_G0027538	protein coding gene	Chr3:123794793-123817867 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028253	protein coding gene	Chr3:129005047-129027430 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025592	protein coding gene	Chr3:115761542-115785798 (+)
CAST/EiJ	MGP_CASTEiJ_G0026994	protein coding gene	Chr3:123183581-123204198 (+)
CBA/J	MGP_CBAJ_G0027513	protein coding gene	Chr3:133393170-133418144 (+)
DBA/2J	MGP_DBA2J_G0027654	protein coding gene	Chr3:119472573-119492160 (+)
FVB/NJ	MGP_FVBNJ_G0027622	protein coding gene	Chr3:117081654-117101327 (+)
LP/J	MGP_LPJ_G0027764	protein coding gene	Chr3:126011095-126034260 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027652	protein coding gene	Chr3:140953638-140975917 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028309	protein coding gene	Chr3:122952916-122975208 (+)
PWK/PhJ	MGP_PWKPhJ_G0026720	protein coding gene	Chr3:119172643-119192645 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026543	protein coding gene	Chr3:121050532-121074454 (+)
WSB/EiJ	MGP_WSBEiJ_G0027074	protein coding gene	Chr3:123683221-123703782 (+)

Human Ortholog

GCLM, glutamate-cysteine ligase modifier subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GCLM, glutamate-cysteine ligase modifier subunit
Synonyms

GLCLR
Links

HGNC:4312

NCBI Gene ID: 2730

neXtProt AC: NX_P48507

UniProt: P48507
Chr Location

1p22.1; chr1:93885199-93909456 (-) GRCh38

MGI Vertebrate Homology

Gclm stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GCLM
Gene Tree

Gclm

Diseases

2 with human GCLM associations

				Human Disease	Mouse Models
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				vascular dementia IDs vascular dementia DOID:8725 DOID:13915 ICD10CM:F01 ICD9CM:290.4 MESH:D015140 MESH:D015161 NCI:C34522 NCI:C34525 UMLS_CUI:C0011263 UMLS_CUI:C0011269

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

27 phenotypes from 2 alleles in 5 genetic backgrounds
61 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

12
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Gclm
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for one null allele show reduced cysteine levels and increased cellular sensitivity to hydrogen peroxide. Homozygotes for another null allele show increased sensitivity to induced hepatotoxicity and neurotoxicity, and ovarian oxidative stress and accelerated ovarian failure in females.

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All GO Annotations

54
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

965
Tissues

153
cDNA Data

11
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gclm

ZFIN gclm

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All Sequences

55
RefSeq

2
UniProt

6
CCDS

CCDS17808.1

Ensembl

ENSMUSG00000028124 (Evidence)
NCBI Gene

14630

			Length	Strain/Species	Flank
genomic	14630	NCBI Gene Model \| MGI Sequence Detail	21659	C57BL/6J	± kb
transcript	NM_008129	RefSeq \| MGI Sequence Detail	2072	ZRU/MplStud
polypeptide	O09172	UniProt \| EBI \| MGI Sequence Detail	274	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007898 glutamate--cysteine ligase regulatory subunit

(term hierarchy)
InterPro Domains

IPR032963 Glutamate--cysteine ligase regulatory subunit

IPR023210 NADP-dependent oxidoreductase domain

IPR036812 NADP-dependent oxidoreductase domain superfamily
GlyGen

O09172 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 12

Primer pair 4

Microarray probesets 7

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MGD-MRK-31068, MGI:2139773

Summaries

All 103

Developmental Gene Expression 12

Diseases 1

Gene Ontology 10

Phenotypes 61
Earliest

J:30588 Tsuchiya K, et al., Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics. 1995 Dec 10;30(3):630-2
Latest

J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893

TSS for Gclm:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31478	Chr3:122039125-122039199 (+)	-44 bp
Tssr31479	Chr3:122039212-122039227 (+)	14 bp
Tssr31480	Chr3:122039230-122039257 (+)	38 bp
Tssr31481	Chr3:122039259-122039271 (+)	59 bp
Tssr31482	Chr3:122039274-122039371 (+)	117 bp
Tssr1039	Chr3:122039392-122039393 (+)	187 bp
Tssr31483	Chr3:122039425-122039478 (+)	246 bp
Tssr31484	Chr3:122039559-122039570 (+)	359 bp
Tssr31486	Chr3:122053143-122053145 (+)	13,938 bp
Tssr31487	Chr3:122055144-122055154 (+)	15,943 bp
Tssr31488	Chr3:122056306-122056346 (+)	17,120 bp
Tssr31489	Chr3:122060201-122060225 (+)	21,007 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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