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Ttf1 Gene Detail
Summary
  • Symbol
    Ttf1
  • Name
    transcription termination factor, RNA polymerase I
  • Feature Type
    protein coding gene
  • IDs
    MGI:105044
    NCBI Gene: 22130
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:28950274-28977668 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    881 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105044
 protein coding gene Chr2:28950211-28977668 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025536
 protein coding gene Chr2:27159901-27192328 (+)
A/J MGP_AJ_G0025513
 protein coding gene Chr2:26123201-26150310 (+)
AKR/J MGP_AKRJ_G0025483
 protein coding gene Chr2:26989674-27020927 (+)
BALB/cJ MGP_BALBcJ_G0025509
 protein coding gene Chr2:26241209-26268552 (+)
C3H/HeJ MGP_C3HHeJ_G0025270
 protein coding gene Chr2:26909092-26940644 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025953
 protein coding gene Chr2:28055284-28084665 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023363
 protein coding gene Chr2:24931548-24958882 (+)
CAST/EiJ MGP_CASTEiJ_G0024733
 protein coding gene Chr2:26818669-26851493 (+)
CBA/J MGP_CBAJ_G0025248
 protein coding gene Chr2:29007560-29039345 (+)
DBA/2J MGP_DBA2J_G0025381
 protein coding gene Chr2:25925417-25953343 (+)
FVB/NJ MGP_FVBNJ_G0025343
 protein coding gene Chr2:25721248-25751470 (+)
LP/J MGP_LPJ_G0025467
 protein coding gene Chr2:27100843-27134903 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025374
 protein coding gene Chr2:29013293-29042559 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026012
 protein coding gene Chr2:26899598-26930130 (+)
PWK/PhJ MGP_PWKPhJ_G0024480
 protein coding gene Chr2:25740870-25768068 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024280
 protein coding gene Chr2:27028437-27055008 (+)
WSB/EiJ MGP_WSBEiJ_G0024802
 protein coding gene Chr2:27032650-27065059 (+)



Homology
more
  • Human Ortholog
    TTF1, transcription termination factor 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTF1, transcription termination factor 1
  • Synonyms
    TTF-1, TTF-I
  • Links
    NCBI Gene ID: 7270
    neXtProt AC: NX_Q15361
    UniProt: Q15361

  • Chr Location
    9q34.13; chr9:132375548-132406851 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    54
  • cDNA Data
    56
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026803 Ensembl Gene Model | MGI Sequence Detail 27395 C57BL/6J ±  kb
transcript ENSMUST00000100237 Ensembl | MGI Sequence Detail 4160 Not Applicable  
polypeptide ENSMUSP00000097809 Ensembl | MGI Sequence Detail 859 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001005 SANT/Myb domain
    IPR053078 Transcription Termination Factor 1-like
Molecular
Reagents
less
  • All nucleic 58
    Genomic 1
    cDNA 56
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-32083, MGI:2139261
References
more
  • Summaries
    All 50
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:24340 Evers R, et al., Different domains of the murine RNA polymerase I-specific termination factor mTTF-I serve distinct functions in transcription termination. EMBO J. 1995 Mar 15;14(6):1248-56
  • Latest
    J:285717 Ishizaki-Asami R, et al., Inositol 1,4,5-trisphosphate receptor 2 as a novel marker of vasculature to delineate processes of cardiopulmonary development. Dev Biol. 2020 Feb 15;458(2):237-245
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory