Psmc5 MGI Mouse Gene Detail - MGI:105047 - protease (prosome, macropain) 26S subunit, ATPase 5

Symbol

Psmc5
Name

protease (prosome, macropain) 26S subunit, ATPase 5
Synonyms

mSUG1, Rpt6

Feature Type

protein coding gene
IDs

MGI:105047
NCBI Gene: 19184
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:106147011-106153938 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 68.89 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

232 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105047	protein coding gene	Chr11:106146980-106153946 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019300	protein coding gene	Chr11:109545066-109553205 (+)
A/J	MGP_AJ_G0019268	protein coding gene	Chr11:104883120-104890026 (+)
AKR/J	MGP_AKRJ_G0019237	protein coding gene	Chr11:108010360-108017326 (+)
BALB/cJ	MGP_BALBcJ_G0019242	protein coding gene	Chr11:105283852-105298314 (+)
C3H/HeJ	MGP_C3HHeJ_G0019051	protein coding gene	Chr11:108299878-108306880 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019692	protein coding gene	Chr11:112895656-112902649 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017316	protein coding gene	Chr11:102160766-102167687 (+)
CAST/EiJ	MGP_CASTEiJ_G0018604	protein coding gene	Chr11:109355608-109362559 (+)
CBA/J	MGP_CBAJ_G0019020	protein coding gene	Chr11:117595359-117602777 (+)
DBA/2J	MGP_DBA2J_G0019132	protein coding gene	Chr11:104350950-104358007 (+)
FVB/NJ	MGP_FVBNJ_G0019123	protein coding gene	Chr11:103852317-103861695 (+)
LP/J	MGP_LPJ_G0019202	protein coding gene	Chr11:109984507-109994160 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019153	protein coding gene	Chr11:116878862-116886863 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019729	protein coding gene	Chr11:108502846-108510379 (+)
PWK/PhJ	MGP_PWKPhJ_G0018369	protein coding gene	Chr11:105447952-105455093 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018160	protein coding gene	Chr11:108265938-108272775 (+)
WSB/EiJ	MGP_WSBEiJ_G0018655	protein coding gene	Chr11:108465831-108472325 (+)

Human Ortholog

PSMC5, proteasome 26S subunit, ATPase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMC5, proteasome 26S subunit, ATPase 5
Synonyms

p45, p45/SUG, RPT6, S8, SUG-1, SUG1, TBP10, TRIP1
Links

HGNC:9552

NCBI Gene ID: 5705

neXtProt AC: NX_P62195

UniProt: P62195
Chr Location

17q23.3; chr17:63827152-63832026 (+) GRCh38

MGI Vertebrate Homology

Psmc5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PSMC5
Gene Tree

Psmc5

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Gene trapped

26
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

Mice homozygous for a phospho-mimetic allele exhibit absence of cocaine locomotor activity sensitization.

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All GO Annotations

40
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

15
cDNA Data

192
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PSMC5

Xenbase psmc5

ZFIN psmc5

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All Sequences

44
RefSeq

2
UniProt

4
CCDS

CCDS25553.1

Ensembl

ENSMUSG00000020708 (Evidence)
NCBI Gene

19184

			Length	Strain/Species	Flank
genomic	19184	NCBI Gene Model \| MGI Sequence Detail	6928	C57BL/6J	± kb
transcript	NM_008950	RefSeq \| MGI Sequence Detail	1277	Not Specified
polypeptide	P62196	UniProt \| EBI \| MGI Sequence Detail	406	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013383 26S proteasome regulatory subunit 8

(term hierarchy)
InterPro Domains

IPR050221 26S Proteasome Regulatory ATPase

IPR041569 AAA ATPase, AAA+ lid domain

IPR003593 AAA+ ATPase domain

IPR003960 ATPase, AAA-type, conserved site

IPR003959 ATPase, AAA-type, core

IPR012340 Nucleic acid-binding, OB-fold

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR032501 Proteasomal ATPase, second OB domain
GlyGen

P62196 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 195

cDNA 193

Other 2

Microarray probesets 5

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MGD-MRK-32086

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 13

Phenotypes 8
Earliest

J:30618 vom Baur E, et al., Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 1996 Jan 2;15(1):110-24
Latest

J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893

TSS for Psmc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105507	Chr11:106146950-106146961 (+)	-55 bp
Tssr105508	Chr11:106146966-106146998 (+)	-29 bp
Tssr105509	Chr11:106146999-106147015 (+)	-4 bp
Tssr105510	Chr11:106153042-106153064 (+)	6,042 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24