P2ry1 MGI Mouse Gene Detail - MGI:105049 - purinergic receptor P2Y, G-protein coupled 1

Symbol

P2ry1
Name

purinergic receptor P2Y, G-protein coupled 1
Synonyms

P2Y1, P2y1r, P2Y1 receptor

Feature Type

protein coding gene
IDs

MGI:105049
NCBI Gene: 18441
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:60910216-60916403 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 29.24 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

203 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105049	protein coding gene	Chr3:60910206-60916403 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027255	protein coding gene	Chr3:59966956-59973145 (+)
A/J	MGP_AJ_G0027215	protein coding gene	Chr3:58201307-58207496 (+)
AKR/J	MGP_AKRJ_G0027185	protein coding gene	Chr3:59358650-59364845 (+)
BALB/cJ	MGP_BALBcJ_G0027228	protein coding gene	Chr3:57944632-57950819 (+)
C3H/HeJ	MGP_C3HHeJ_G0026971	protein coding gene	Chr3:59548475-59554660 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027674	protein coding gene	Chr3:62230383-62236570 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025028	protein coding gene	Chr3:54922779-54928974 (+)
CAST/EiJ	MGP_CASTEiJ_G0026423	protein coding gene	Chr3:59742504-59748689 (+)
CBA/J	MGP_CBAJ_G0026947	protein coding gene	Chr3:64268282-64274467 (+)
DBA/2J	MGP_DBA2J_G0027081	protein coding gene	Chr3:57608987-57615180 (+)
FVB/NJ	MGP_FVBNJ_G0027049	protein coding gene	Chr3:56494430-56500617 (+)
LP/J	MGP_LPJ_G0027192	protein coding gene	Chr3:60813753-60819942 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027066	protein coding gene	Chr3:68534084-68541513 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027732	protein coding gene	Chr3:59276307-59282494 (+)
PWK/PhJ	MGP_PWKPhJ_G0026155	protein coding gene	Chr3:57257579-57263822 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025968	protein coding gene	Chr3:58867062-58873284 (+)
WSB/EiJ	MGP_WSBEiJ_G0026497	protein coding gene	Chr3:59378406-59384591 (+)

Human Ortholog

P2RY1, purinergic receptor P2Y1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

P2RY1, purinergic receptor P2Y1
Synonyms

P2Y1, SARCC
Links

HGNC:8539

NCBI Gene ID: 5028

neXtProt AC: NX_P47900

UniProt: P47900
Chr Location

3q25.2; chr3:152835131-152841439 (+) GRCh38

MGI Vertebrate Homology

P2ry1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: P2RY1
Gene Tree

P2ry1

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
61 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving P2ry1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for either one of two independently generated knock-out alleles exhibit decreased platelet aggregation, increased bleeding time, and resistance to induced thromboembolism.

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All GO Annotations

101
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

45
cDNA Data

7
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase p2ry1

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All Sequences

43
RefSeq

4
UniProt

4
CCDS

CCDS17377.1

Ensembl

ENSMUSG00000027765 (Evidence)
NCBI Gene

18441

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027765	Ensembl Gene Model \| MGI Sequence Detail	6188	C57BL/6J	± kb
transcript	ENSMUST00000193201	Ensembl \| MGI Sequence Detail	3614	Not Applicable
polypeptide	ENSMUSP00000142006	Ensembl \| MGI Sequence Detail	373	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001568 P2Y purinoceptor 1

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000142 P2Y purinoceptor 1
GlyGen

P49650 4 sites

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 5

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MGD-MRK-32088

Summaries

All 114

Developmental Gene Expression 4

Diseases 1

Gene Ontology 10

Phenotypes 61
Earliest

J:25964 Tokuyama Y, et al., Cloning of rat and mouse P2Y purinoceptors. Biochem Biophys Res Commun. 1995 Jun 6;211(1):211-8
Latest

J:349897 Schappe MS, et al., A vagal reflex evoked by airway closure. Nature. 2024 Mar;627(8005):830-838

TSS for P2ry1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29331	Chr3:60910199-60910204 (+)	-14 bp
Tssr29332	Chr3:60910207-60910232 (+)	4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24