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Ksr1 Gene Detail
Summary
  • Symbol
    Ksr1
  • Name
    kinase suppressor of ras 1
  • Synonyms
    B-KSR1, D11Bhm183e, D11Bhm184e
  • Feature Type
    protein coding gene
  • IDs
    MGI:105051
    NCBI Gene: 16706
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78904266-79037233 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3776 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105051
 protein coding gene Chr11:78904266-79037357 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018793
 protein coding gene Chr11:80075385-80217895 (-)
A/J MGP_AJ_G0018760
 protein coding gene Chr11:77004503-77138144 (-)
AKR/J MGP_AKRJ_G0018730
 protein coding gene Chr11:79318689-79460500 (-)
BALB/cJ MGP_BALBcJ_G0018733
 protein coding gene Chr11:77415130-77555055 (-)
C3H/HeJ MGP_C3HHeJ_G0018547
 protein coding gene Chr11:79362083-79499149 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019185
 protein coding gene Chr11:82549855-82690633 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016820
 protein coding gene Chr11:73959995-74092513 (-)
CAST/EiJ MGP_CASTEiJ_G0018102
 protein coding gene Chr11:79832388-79980049 (-)
CBA/J MGP_CBAJ_G0018518
 protein coding gene Chr11:86129977-86286104 (-)
DBA/2J MGP_DBA2J_G0018626
 protein coding gene Chr11:76567056-76701325 (-)
FVB/NJ MGP_FVBNJ_G0018615
 protein coding gene Chr11:76161293-76303375 (-)
LP/J MGP_LPJ_G0018696
 protein coding gene Chr11:80597040-80732585 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018642
 protein coding gene Chr11:86514923-86647415 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019225
 protein coding gene Chr11:79578766-79717595 (-)
PWK/PhJ MGP_PWKPhJ_G0017872
 protein coding gene Chr11:77373565-77511733 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017663
 protein coding gene Chr11:79191079-79325016 (-)
WSB/EiJ MGP_WSBEiJ_G0018154
 protein coding gene Chr11:79396319-79537216 (-)



Homology
more
  • Human Ortholog
    KSR1, kinase suppressor of ras 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KSR1, kinase suppressor of ras 1
  • Synonyms
    KSR, RSU2
  • Links
    NCBI Gene ID: 8844
    neXtProt AC: NX_Q8IVT5
    UniProt: Q8IVT5

  • Chr Location
    17q11.2; chr17:27456448-27626438 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KSR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit disorganized hair follicles and a decreased susceptibility to papilloma formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    31
  • cDNA Data
    8
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018334 Ensembl Gene Model | MGI Sequence Detail 132968 C57BL/6J ±  kb
    transcript ENSMUST00000018478 Ensembl | MGI Sequence Detail 5495 Not Applicable  
    polypeptide ENSMUSP00000018478 Ensembl | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000009591 kinase suppressor of Ras 1
      (term hierarchy)
    • PDB
      1KBE, 1KBF, 2LPE
    • EC
      2.7.11.1
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR046861 Kinase suppressor RAS 1, N-terminal helical hairpin
      IPR046933 Kinase suppressor RAS 1, N-terminal helical hairpin superfamily
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050167 Serine/threonine-protein kinase
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 9
      cDNA 8
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-32090, MGD-MRK-35271, MGD-MRK-35272, MGI:106811, MGI:106812, MGI:2144543
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 3
      Gene Ontology 20
      Phenotypes 34
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:352233 Ingersoll MA, et al., KSR1 Knockout Mouse Model Demonstrates MAPK Pathway's Key Role in Cisplatin- and Noise-induced Hearing Loss. J Neurosci. 2024 May 1;44(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory