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Hsph1 Gene Detail
Summary
  • Symbol
    Hsph1
  • Name
    heat shock 105kDa/110kDa protein 1
  • Synonyms
    Hsp105, HSP110, hsp110/105, hsp-E7I
  • Feature Type
    protein coding gene
  • IDs
    MGI:105053
    NCBI Gene: 15505
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:149537752-149559841 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 89.18 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    582 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105053
 protein coding gene Chr5:149537752-149562594 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030405
 protein coding gene Chr5:155460133-155485494 (-)
A/J MGP_AJ_G0030378
 protein coding gene Chr5:148824365-148847022 (-)
AKR/J MGP_AKRJ_G0030305
 protein coding gene Chr5:153420209-153442358 (-)
BALB/cJ MGP_BALBcJ_G0030387
 protein coding gene Chr5:150086667-150108665 (-)
C3H/HeJ MGP_C3HHeJ_G0030101
 protein coding gene Chr5:154418400-154441780 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030842
 protein coding gene Chr5:161163128-161186514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028055
 protein coding gene Chr5:143168365-143190691 (-)
CAST/EiJ MGP_CASTEiJ_G0029503
 protein coding gene Chr5:154045147-154067035 (-)
CBA/J MGP_CBAJ_G0030079
 protein coding gene Chr5:167948863-167970919 (-)
DBA/2J MGP_DBA2J_G0030223
 protein coding gene Chr5:148477178-148499538 (-)
FVB/NJ MGP_FVBNJ_G0030177
 protein coding gene Chr5:147730872-147753306 (-)
LP/J MGP_LPJ_G0030310
 protein coding gene Chr5:156157322-156180668 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030213
 protein coding gene Chr5:170050085-170072995 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030872
 protein coding gene Chr5:153356788-153378793 (-)
PWK/PhJ MGP_PWKPhJ_G0029217
 protein coding gene Chr5:147642233-147664424 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029053
 protein coding gene Chr5:150663046-150684872 (-)
WSB/EiJ MGP_WSBEiJ_G0029580
 protein coding gene Chr5:154173041-154195133 (-)



Homology
more
  • Human Ortholog
    HSPH1, heat shock protein family H (Hsp110) member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPH1, heat shock protein family H (Hsp110) member 1
  • Synonyms
    HSP105, HSP105A, HSP105B, NY-CO-25
  • Links
    NCBI Gene ID: 10808
    neXtProt AC: NX_Q92598
    UniProt: Q92598

  • Chr Location
    13q12.3; chr13:31134973-31162388 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to decreased susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    83
  • cDNA Data
    258
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029657 Ensembl Gene Model | MGI Sequence Detail 22090 C57BL/6J ±  kb
transcript ENSMUST00000201452 Ensembl | MGI Sequence Detail 3140 Not Applicable  
polypeptide ENSMUSP00000144654 Ensembl | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000003410 heat shock protein 105 kDa
    (term hierarchy)
  • InterPro Domains
    IPR043129 ATPase, nucleotide binding domain
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR050451 Heat Shock Protein 70 (HSP70)
    IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
    IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
    IPR042053 HSPH1, nucleotide-binding domain
  • GlyGen
    Q61699 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 261
    Genomic 1
    cDNA 259
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-32092, MGI:2140965
References
more
  • Summaries
    All 64
    Developmental Gene Expression 7
    Gene Ontology 15
    Phenotypes 12
  • Earliest
    J:30122 Yasuda K, et al., Cloning and expression of murine high molecular mass heat shock proteins, HSP105. J Biol Chem. 1995 Dec 15;270(50):29718-23
  • Latest
    J:331267 de Thonel A, et al., CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. Nat Commun. 2022 Nov 16;13(1):7002
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory