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Cobl Gene Detail
Summary
  • Symbol
    Cobl
  • Name
    cordon-bleu WH2 repeat
  • Synonyms
    C530045F18Rik, mKIAA0633
  • Feature Type
    protein coding gene
  • IDs
    MGI:105056
    NCBI Gene: 12808
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:12186676-12415022 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 7.30 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6299 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105056
 protein coding gene Chr11:12186608-12415022 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018049
 protein coding gene Chr11:9550045-9787093 (-)
A/J MGP_AJ_G0018022
 protein coding gene Chr11:9201364-9432120 (-)
AKR/J MGP_AKRJ_G0017986
 protein coding gene Chr11:9579580-9813537 (-)
BALB/cJ MGP_BALBcJ_G0017990
 protein coding gene Chr11:9238339-9468854 (-)
C3H/HeJ MGP_C3HHeJ_G0017803
 protein coding gene Chr11:9473730-9721264 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018442
 protein coding gene Chr11:9869428-10106424 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016100
 protein coding gene Chr11:8742197-8971757 (-)
CAST/EiJ MGP_CASTEiJ_G0017365
 protein coding gene Chr11:9496416-9733368 (-)
CBA/J MGP_CBAJ_G0017778
 protein coding gene Chr11:10547447-10792996 (-)
DBA/2J MGP_DBA2J_G0017888
 protein coding gene Chr11:9130620-9363772 (-)
FVB/NJ MGP_FVBNJ_G0017880
 protein coding gene Chr11:9045015-9276866 (-)
LP/J MGP_LPJ_G0017959
 protein coding gene Chr11:9630459-9868878 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017906
 protein coding gene Chr11:10264254-10519970 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018483
 protein coding gene Chr11:9620179-9873780 (-)
PWK/PhJ MGP_PWKPhJ_G0017145
 protein coding gene Chr11:9168926-9403716 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016942
 protein coding gene Chr11:9458563-9711863 (-)
WSB/EiJ MGP_WSBEiJ_G0017419
 protein coding gene Chr11:9352379-9589471 (-)



Homology
more
  • Human Ortholog
    COBL, cordon-bleu WH2 repeat protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COBL, cordon-bleu WH2 repeat protein
  • Links
    NCBI Gene ID: 23242
    neXtProt AC: NX_O75128
    UniProt: O75128

  • Chr Location
    7p12.1; chr7:51016212-51316818 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for this mutation do not display a phenotype. However, the allele exacerbates the neural tube defects seen in the loop tail mouse.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1025
  • Tissues
    85
  • cDNA Data
    51
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12808 NCBI Gene Model | MGI Sequence Detail 228347 C57BL/6J ±  kb
    transcript NM_172496 RefSeq | MGI Sequence Detail 5597 ZRU/MplStud  
    polypeptide Q5NBX1 UniProt | EBI | MGI Sequence Detail 1337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 52
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32095, MGI:2444561
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:28764 Gasca S, et al., Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. Dev Genet. 1995;17(2):141-54
    • Latest
      J:329940 Juan AM, et al., Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development. Mol Cell. 2022 Oct 6;82(19):3613-3631.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory