Slc9a3 MGI Mouse Gene Detail - MGI:105064 - solute carrier family 9 (sodium/hydrogen exchanger), member 3

Symbol

Slc9a3
Name

solute carrier family 9 (sodium/hydrogen exchanger), member 3
Synonyms

9030624O13Rik, NHE-3, NHE3

Feature Type

protein coding gene
IDs

MGI:105064
NCBI Gene: 105243
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:74269576-74317561 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 40.15 cM
Mapping Data

5 experiments

SNPs within 2kb

1222 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105064	protein coding gene	Chr13:74234374-74317561 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020759	protein coding gene	Chr13:74619066-74664715 (+)
A/J	MGP_AJ_G0020715	protein coding gene	Chr13:71948331-71993969 (+)
AKR/J	MGP_AKRJ_G0020689	protein coding gene	Chr13:74203998-74249704 (+)
BALB/cJ	MGP_BALBcJ_G0020712	protein coding gene	Chr13:72442714-72488352 (+)
C3H/HeJ	MGP_C3HHeJ_G0020506	protein coding gene	Chr13:73889053-73936126 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021149	protein coding gene	Chr13:77091064-77136406 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018716	protein coding gene	Chr13:68774932-68825369 (+)
CAST/EiJ	MGP_CASTEiJ_G0020023	protein coding gene	Chr13:72966572-73013528 (+)
CBA/J	MGP_CBAJ_G0020465	protein coding gene	Chr13:79963664-80008210 (+)
DBA/2J	MGP_DBA2J_G0020590	protein coding gene	Chr13:71766170-71810711 (+)
FVB/NJ	MGP_FVBNJ_G0020570	protein coding gene	Chr13:70789942-70835591 (+)
LP/J	MGP_LPJ_G0020663	protein coding gene	Chr13:74850224-74895902 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020598	protein coding gene	Chr13:78360532-78406200 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021188	protein coding gene	Chr13:73522158-73567803 (+)
PWK/PhJ	MGP_PWKPhJ_G0019777	protein coding gene	Chr13:70509702-70555979 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019600	protein coding gene	Chr13:70002346-70047440 (+)
WSB/EiJ	MGP_WSBEiJ_G0020081	protein coding gene	Chr13:74078418-74124080 (+)

Human Ortholog

SLC9A3, solute carrier family 9 member A3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC9A3, solute carrier family 9 member A3
Synonyms

DIAR8, NHE-3, NHE3
Links

HGNC:11073

NCBI Gene ID: 6550

neXtProt AC: NX_P48764

UniProt: P48764
Chr Location

5p15.33; chr5:470456-524449 (-) GRCh38

MGI Vertebrate Homology

Slc9a3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC9A3
Gene Tree

Slc9a3

Diseases

1 with human SLC9A3 associations

				Human Disease	Mouse Models
				congenital secretory sodium diarrhea 8 IDs congenital secretory sodium diarrhea 8 DOID:0060777 ICD10CM:P78.3 OMIM:616868 ORDO:103908

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
73 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

11
Genomic Mutations

1 involving Slc9a3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutant mice have diarrhea associated with defects of renal and intestinal absorption. Males are infertile.

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All GO Annotations

40
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

63
cDNA Data

6
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc9a3

ZFIN slc9a3.1, slc9a3.2

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All Sequences

42
RefSeq

6
UniProt

3
CCDS

CCDS36731.1

Ensembl

ENSMUSG00000036123 (Evidence)
NCBI Gene

105243

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036123	Ensembl Gene Model \| MGI Sequence Detail	47986	C57BL/6J	± kb
transcript	ENSMUST00000225423	Ensembl \| MGI Sequence Detail	2589	Not Applicable
polypeptide	ENSMUSP00000153255	Ensembl \| MGI Sequence Detail	862	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015214 sodium/hydrogen exchanger 3

(term hierarchy)
InterPro Domains

IPR006153 Cation/H+ exchanger

IPR018422 Cation/H+ exchanger, CPA1 family

IPR004709 Na+/H+ exchanger

IPR018410 Na+/H+ exchanger, isoforms 3/5

IPR011256 Regulatory factor, effector binding domain superfamily

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All nucleic 10

cDNA 7

Primer pair 3

Microarray probesets 3

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MGD-MRK-32103, MGI:2145314

Summaries

All 142

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 73
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc9a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120348	Chr13:74269524-74269540 (+)	-44 bp
Tssr120349	Chr13:74269554-74269565 (+)	-16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24