About   Help   FAQ
Adcyap1 Gene Detail
Summary
  • Symbol
    Adcyap1
  • Name
    adenylate cyclase activating polypeptide 1
  • Synonyms
    PACAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:105094
    NCBI Gene: 11516
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:93506448-93513967 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 60.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105094
 protein coding gene Chr17:93506445-93513967 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024117
 protein coding gene Chr17:96912239-96918311 (+)
A/J MGP_AJ_G0024077
 protein coding gene Chr17:93726801-93732871 (+)
AKR/J MGP_AKRJ_G0024046
 protein coding gene Chr17:95272056-95278146 (+)
BALB/cJ MGP_BALBcJ_G0024078
 protein coding gene Chr17:93573747-93579816 (+)
C3H/HeJ MGP_C3HHeJ_G0023843
 protein coding gene Chr17:96206843-96212915 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024523
 protein coding gene Chr17:100239829-100245892 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021962
 protein coding gene Chr17:88550706-88556779 (+)
CAST/EiJ MGP_CASTEiJ_G0023322
 protein coding gene Chr17:97158124-97164220 (+)
CBA/J MGP_CBAJ_G0023817
 protein coding gene Chr17:104398966-104407200 (+)
DBA/2J MGP_DBA2J_G0023945
 protein coding gene Chr17:92090040-92096124 (+)
FVB/NJ MGP_FVBNJ_G0023911
 protein coding gene Chr17:91568053-91574109 (+)
LP/J MGP_LPJ_G0024029
 protein coding gene Chr17:97631465-97637538 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023939
 protein coding gene Chr17:104818278-104824341 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024568
 protein coding gene Chr17:95846877-95852949 (+)
PWK/PhJ MGP_PWKPhJ_G0023067
 protein coding gene Chr17:91831558-91837677 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022878
 protein coding gene Chr17:92670764-92676851 (+)
WSB/EiJ MGP_WSBEiJ_G0023388
 protein coding gene Chr17:96787748-96793810 (+)



Homology
more
  • Human Ortholog
    ADCYAP1, adenylate cyclase activating polypeptide 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADCYAP1, adenylate cyclase activating polypeptide 1
  • Synonyms
    PACAP
  • Links
    NCBI Gene ID: 116
    neXtProt AC: NX_P18509
    UniProt: P18509

  • Chr Location
    18p11.32; chr18:904411-912172 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADCYAP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 4 alleles in 7 genetic backgrounds
    137 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    108
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1113
  • Tissues
    161
  • cDNA Data
    18
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11516 NCBI Gene Model | MGI Sequence Detail 7520 C57BL/6J ±  kb
    transcript NM_001409525 RefSeq | MGI Sequence Detail 3480 C57BL/6  
    polypeptide O70176 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 20
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32134
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 24
      Gene Ontology 10
      Phenotypes 137
    • Earliest
      J:29992 Okazaki K, et al., Characterization of murine PACAP mRNA. Peptides. 1995;16(7):1295-9
    • Latest
      J:349438 Basu R, et al., Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs. Mol Metab. 2024 Jun;84:101951
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory