Rps2 MGI Mouse Gene Detail - MGI:105110

Symbol

Rps2
Name

ribosomal protein S2
Synonyms

Llrep3, Rps2

Feature Type

protein coding gene
IDs

MGI:105110
NCBI Gene: 16898
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:24939037-24940901 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.51 cM, cytoband A3.3
Mapping Data

2 experiments

SNPs within 2kb

184 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105110	protein coding gene	Chr17:24937090-24940903 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023318	protein coding gene	Chr17:23731905-23736885 (+)
A/J	MGP_AJ_G0023278	protein coding gene	Chr17:23083116-23086847 (+)
AKR/J	MGP_AKRJ_G0023245	protein coding gene	Chr17:23162042-23165773 (+)
BALB/cJ	MGP_BALBcJ_G0023283	protein coding gene	Chr17:23278141-23284080 (+)
C3H/HeJ	MGP_C3HHeJ_G0023043	protein coding gene	Chr17:23521989-23529406 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023726	protein coding gene	Chr17:24784379-24788114 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021201	protein coding gene	Chr17:20551908-20556240 (+)
CAST/EiJ	MGP_CASTEiJ_G0022545	protein coding gene	Chr17:23379898-23384038 (+)
CBA/J	MGP_CBAJ_G0023019	protein coding gene	Chr17:25635964-25642463 (+)
DBA/2J	MGP_DBA2J_G0023148	protein coding gene	Chr17:22677360-22679767 (+)
FVB/NJ	MGP_FVBNJ_G0023118	protein coding gene	Chr17:22394878-22399020 (+)
LP/J	MGP_LPJ_G0023225	protein coding gene	Chr17:24044775-24045251 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023137	protein coding gene	Chr17:25331129-25332909 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023764	protein coding gene	Chr17:23444175-23447856 (+)
PWK/PhJ	MGP_PWKPhJ_G0022294	protein coding gene	Chr17:21424393-21426408 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022119	protein coding gene	Chr17:21648705-21649879 (-)
WSB/EiJ	MGP_WSBEiJ_G0022608	protein coding gene	Chr17:23520273-23522004 (+)

Human Ortholog

RPS2, ribosomal protein S2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS2, ribosomal protein S2
Synonyms

LLREP3, S2, uS5
Links

HGNC:10404

NCBI Gene ID: 6187

neXtProt AC: NX_P15880

UniProt: P15880
Chr Location

16p13.3; chr16:1962058-1964841 (-) GRCh38

MGI Vertebrate Homology

Rps2 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS2
Gene Tree

Rps2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

4
Targeted

4
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an allele with a point mutation die prior to weaning. Mice heterozygous for the allele exhibit reduced body fat, mild muscle weakness, and increased circulating creatine kinase level.

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

4
cDNA Data

25
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RPS2

Xenbase rps2

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All Sequences

99
RefSeq

2
UniProt

12
CCDS

CCDS37493.1

Ensembl

ENSMUSG00000044533 (Evidence)
NCBI Gene

16898

			Length	Strain/Species	Flank
genomic	16898	NCBI Gene Model \| MGI Sequence Detail	1865	C57BL/6J	± kb
transcript	NM_008503	RefSeq \| MGI Sequence Detail	1005	C57BL/6
polypeptide	P25444	UniProt \| EBI \| MGI Sequence Detail	293	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000014263 eukaryotic-type small ribosomal subunit protein uS5

(term hierarchy)
PDB

7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR020568 Ribosomal protein uS5 domain 2-type superfamily

IPR000851 Small ribosomal subunit protein uS5

IPR005324 Small ribosomal subunit protein uS5, C-terminal

IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup

IPR005711 Small ribosomal subunit protein uS5, eukaryotic/archaeal

IPR013810 Small ribosomal subunit protein uS5, N-terminal

IPR018192 Small ribosomal subunit protein uS5, N-terminal, conserved site
GlyGen

P25444 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 29

Genomic 2

cDNA 26

Other 1

Microarray probesets 17

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MGD-MRK-32150

Summaries

All 53

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 8
Earliest

J:19957 Heller DL, et al., A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988 Jul;8(7):2797-803
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Rps2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143066	Chr17:24937062-24937092 (+)	-1,960 bp
Tssr143067	Chr17:24938927-24938930 (+)	-108 bp
Tssr143068	Chr17:24939017-24939031 (+)	-13 bp
Tssr143069	Chr17:24939041-24939057 (+)	12 bp
Tssr143070	Chr17:24939076-24939092 (+)	47 bp
Tssr143071	Chr17:24939155-24939163 (+)	122 bp
Tssr143072	Chr17:24939225-24939236 (+)	194 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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