Gucy2f MGI Mouse Gene Detail - MGI:105119

Symbol

Gucy2f
Name

guanylate cyclase 2f
Synonyms

GC2, GC-F

Feature Type

protein coding gene
IDs

MGI:105119
NCBI Gene: 245650
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

ChrX:140864156-140979927 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 62.85 cM
Mapping Data

3 experiments

SNPs within 2kb

2025 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105119	protein coding gene	ChrX:140862282-140980399 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036147	protein coding gene	ChrX:139582246-139698870 (-)
A/J	MGP_AJ_G0036124	protein coding gene	ChrX:138985988-139099334 (-)
AKR/J	MGP_AKRJ_G0036050	protein coding gene	ChrX:143424403-143545929 (-)
BALB/cJ	MGP_BALBcJ_G0036115	protein coding gene	ChrX:137219935-137330061 (-)
C3H/HeJ	MGP_C3HHeJ_G0035823	protein coding gene	ChrX:139690005-139799494 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036638	protein coding gene	ChrX:143590343-143717150 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033462	protein coding gene	ChrX:130561803-130663946 (-)
CAST/EiJ	MGP_CASTEiJ_G0035114	protein coding gene	ChrX:120409041-120510105 (-)
CBA/J	MGP_CBAJ_G0035800	protein coding gene	ChrX:148081426-148199958 (-)
DBA/2J	MGP_DBA2J_G0035958	protein coding gene	ChrX:138044695-138169139 (-)
FVB/NJ	MGP_FVBNJ_G0035892	protein coding gene	ChrX:137271785-137386713 (-)
LP/J	MGP_LPJ_G0036049	protein coding gene	ChrX:140530021-140645561 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035928	protein coding gene	ChrX:155690595-155813649 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036675	protein coding gene	ChrX:138890295-139002325 (-)
PWK/PhJ	MGP_PWKPhJ_G0034808	protein coding gene	ChrX:117218344-117333398 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034633	protein coding gene	ChrX:120925993-121030568 (-)
WSB/EiJ	MGP_WSBEiJ_G0035249	protein coding gene	ChrX:137296390-137402276 (-)

Human Ortholog

GUCY2F, guanylate cyclase 2F, retinal

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GUCY2F, guanylate cyclase 2F, retinal
Synonyms

CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2
Links

HGNC:4691

NCBI Gene ID: 2986

neXtProt AC: NX_P51841

UniProt: P51841
Chr Location

Xq22.3-q23; chrX:109372906-109482086 (-) GRCh38

MGI Vertebrate Homology

Gucy2f stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GUCY2F
Gene Tree

Gucy2f

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
1 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

4 strains or lines available

Mice homozygous for a knock-out allele exhibit abnormal retinal rod electrophysiology.

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All GO Annotations

23
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

97
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gucy2f

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All Sequences

37
RefSeq

10
UniProt

1
CCDS

CCDS30446.1

Ensembl

ENSMUSG00000042282 (Evidence)
NCBI Gene

245650

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042282	Ensembl Gene Model \| MGI Sequence Detail	115772	C57BL/6J	± kb
transcript	ENSMUST00000042530	Ensembl \| MGI Sequence Detail	8122	Not Applicable
polypeptide	ENSMUSP00000044521	Ensembl \| MGI Sequence Detail	1108	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008354 retinal guanylyl cyclase 2

(term hierarchy)
EC

4.6.1.2
InterPro Domains

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase

IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site

IPR050401 Cyclic nucleotide synthase

IPR029787 Nucleotide cyclase

IPR028082 Periplasmic binding protein-like I

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001828 Receptor, ligand binding region

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 1

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MGD-MRK-32159

Summaries

All 38

Developmental Gene Expression 3

Diseases 1

Gene Ontology 9

Phenotypes 9
Earliest

J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
Latest

J:280369 Dizhoor AM, et al., Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness. J Biol Chem. 2019 Sep 13;294(37):13729-13739

TSS for Gucy2f:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164277	ChrX:140979992-140979997 (-)	-68 bp
Tssr164276	ChrX:140979957-140979978 (-)	-41 bp
Tssr164275	ChrX:140979950-140979956 (-)	-26 bp
Tssr164274	ChrX:140979940-140979945 (-)	-16 bp
Tssr164273	ChrX:140979913-140979920 (-)	10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24