Stt3a MGI Mouse Gene Detail - MGI:105124 - STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)

Symbol

Stt3a
Name

STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Synonyms

Itm1

Feature Type

protein coding gene
IDs

MGI:105124
NCBI Gene: 16430
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:36640640-36678918 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 20.67 cM
Mapping Data

8 experiments

SNPs within 2kb

1035 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105124	protein coding gene	Chr9:36640640-36678975 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034555	protein coding gene	Chr9:34634427-34676746 (-)
A/J	MGP_AJ_G0034534	protein coding gene	Chr9:33750388-33785343 (-)
AKR/J	MGP_AKRJ_G0034461	protein coding gene	Chr9:34496322-34531088 (-)
BALB/cJ	MGP_BALBcJ_G0034525	protein coding gene	Chr9:33586972-33627298 (-)
C3H/HeJ	MGP_C3HHeJ_G0034238	protein coding gene	Chr9:34898999-34940913 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035047	protein coding gene	Chr9:35770500-35810404 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031973	protein coding gene	Chr9:32882273-32919281 (-)
CAST/EiJ	MGP_CASTEiJ_G0033559	protein coding gene	Chr9:34606123-34642543 (-)
CBA/J	MGP_CBAJ_G0034211	protein coding gene	Chr9:36991968-37030231 (-)
DBA/2J	MGP_DBA2J_G0034369	protein coding gene	Chr9:33804084-33837491 (-)
FVB/NJ	MGP_FVBNJ_G0034310	protein coding gene	Chr9:33060753-33094486 (-)
LP/J	MGP_LPJ_G0034454	protein coding gene	Chr9:34886332-34924415 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034356	protein coding gene	Chr9:38662930-38702097 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035066	protein coding gene	Chr9:34422773-34462591 (-)
PWK/PhJ	MGP_PWKPhJ_G0033265	protein coding gene	Chr9:33698611-33739768 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033099	protein coding gene	Chr9:34635216-34676215 (-)
WSB/EiJ	MGP_WSBEiJ_G0033675	protein coding gene	Chr9:34220080-34263790 (-)

Human Ortholog

STT3A, STT3 oligosaccharyltransferase complex catalytic subunit A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STT3A, STT3 oligosaccharyltransferase complex catalytic subunit A
Synonyms

CDG1WAD, CDG1WAR, ITM1, STT3-A, TMC
Links

HGNC:6172

NCBI Gene ID: 3703

neXtProt AC: NX_P46977

UniProt: P46977
Chr Location

11q24.2; chr11:125591712-125625215 (+) GRCh38

MGI Vertebrate Homology

Stt3a stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: STT3A
Gene Tree

Stt3a

Diseases

1 with human STT3A associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation Iw IDs congenital disorder of glycosylation Iw DOID:0080572 OMIM:615596 ORDO:370921

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

55
Endonuclease-mediated

2
Gene trapped

51
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

8
cDNA Data

256
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stt3a

ZFIN stt3a

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All Sequences

99
RefSeq

2
UniProt

16
CCDS

CCDS52768.1

Ensembl

ENSMUSG00000032116 (Evidence)
NCBI Gene

16430

			Length	Strain/Species	Flank
genomic	16430	NCBI Gene Model \| MGI Sequence Detail	38279	C57BL/6J	± kb
transcript	NM_008408	RefSeq \| MGI Sequence Detail	5810	ZRU/MplStud
polypeptide	P46978	UniProt \| EBI \| MGI Sequence Detail	705	Not Applicable

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UniProt

16 Sequences
Protein Ontology

PR:000015782 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

(term hierarchy)
EC

2.4.99.18
InterPro Domains

IPR048307 Oligosaccharyl transferase STT3, N-terminal domain

IPR003674 Oligosaccharyl transferase, STT3 subunit
GlyGen

P46978 4 sites, 5 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 260

Genomic 3

cDNA 257

Microarray probesets 8

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MGD-MRK-32165, MGI:2142927, MGI:2143357

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 7
Earliest

J:31349 Hong G, et al., Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9. Genomics. 1996 Feb 1;31(3):295-300
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Stt3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88804	Chr9:36678891-36678934 (-)	5 bp
Tssr88803	Chr9:36678868-36678882 (-)	43 bp
Tssr88802	Chr9:36671580-36671584 (-)	7,336 bp
Tssr88801	Chr9:36670535-36670549 (-)	8,376 bp
Tssr88800	Chr9:36668317-36668332 (-)	10,593 bp
Tssr88799	Chr9:36668296-36668307 (-)	10,616 bp
Tssr88798	Chr9:36642356-36642361 (-)	36,559 bp
Tssr88797	Chr9:36641318-36641321 (-)	37,598 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24